Detailed Information on Publication Record
2013
Long-term vagus nerve stimulation in children with focal epilepsy
RYZÍ, Michal, Milan BRÁZDIL, Zdeněk NOVÁK, Jan CHRASTINA, Hana OŠLEJŠKOVÁ et. al.Basic information
Original name
Long-term vagus nerve stimulation in children with focal epilepsy
Authors
RYZÍ, Michal (203 Czech Republic, guarantor, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Zdeněk NOVÁK (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Hana OŠLEJŠKOVÁ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Robert KUBA (203 Czech Republic, belonging to the institution)
Edition
ACTA NEUROLOGICA SCANDINAVICA, MALDEN, USA, WILEY-BLACKWELL, 2013, 0001-6314
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.437
RIV identification code
RIV/00216224:14110/13:00067788
Organization unit
Faculty of Medicine
UT WoS
000317859900006
Keywords in English
child neurology; epilepsy; quality of life; seizures; treatment
Tags
International impact, Reviewed
Změněno: 27/5/2013 16:52, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Objectives – The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods – We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 +/- 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results – The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 +/- 0.6 per year preoperatively and 0.3 +/- 0.5 per year post-operatively. The mean number of days of urgent hospitalization per patient was 9.3 +/- 6.1 per year preoperatively and 1.3 +/- 1.8 per year postoperatively. Conclusions – Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.