RYZÍ, Michal, Milan BRÁZDIL, Zdeněk NOVÁK, Jan CHRASTINA, Hana OŠLEJŠKOVÁ, Ivan REKTOR and Robert KUBA. Long-term vagus nerve stimulation in children with focal epilepsy. ACTA NEUROLOGICA SCANDINAVICA. MALDEN, USA: WILEY-BLACKWELL, 2013, vol. 127, No 5, p. 316-322. ISSN 0001-6314. Available from: https://dx.doi.org/10.1111/ane.12009.
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Basic information
Original name Long-term vagus nerve stimulation in children with focal epilepsy
Authors RYZÍ, Michal (203 Czech Republic, guarantor, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Zdeněk NOVÁK (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Hana OŠLEJŠKOVÁ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Robert KUBA (203 Czech Republic, belonging to the institution).
Edition ACTA NEUROLOGICA SCANDINAVICA, MALDEN, USA, WILEY-BLACKWELL, 2013, 0001-6314.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.437
RIV identification code RIV/00216224:14110/13:00067788
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/ane.12009
UT WoS 000317859900006
Keywords in English child neurology; epilepsy; quality of life; seizures; treatment
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 27/5/2013 16:52.
Abstract
Objectives – The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods – We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 +/- 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results – The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 +/- 0.6 per year preoperatively and 0.3 +/- 0.5 per year post-operatively. The mean number of days of urgent hospitalization per patient was 9.3 +/- 6.1 per year preoperatively and 1.3 +/- 1.8 per year postoperatively. Conclusions – Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.
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