Severe cobalt intoxication following hip replacement revision:
Clinical features and outcome

J 2012

Severe cobalt intoxication following hip replacement revision: Clinical features and outcome

PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH

Basic information

Original name

Severe cobalt intoxication following hip replacement revision: Clinical features and outcome

Authors

PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH

Edition

CLINICAL TOXICOLOGY, NEW YORK, INFORMA HEALTHCARE, 2012, 1556-3650

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30211 Orthopaedics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.592

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3109/15563650.2012.670244

UT WoS

000302024600006

Keywords in English

Cobalt; Hip prosthesis; Cardiomyopathy; Hypothyreosis; Hearing loss; DMPS; Chromium

Abstract

V originále

Context. Cobalt intoxication has become more frequent due to the wide use of metal hip implants. Case details. A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved. Conclusion. We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit.

Citovat

PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH. Severe cobalt intoxication following hip replacement revision: Clinical features and outcome. CLINICAL TOXICOLOGY. NEW YORK: INFORMA HEALTHCARE, 2012, vol. 50, No 4, p. 262-265. ISSN 1556-3650. Available from: https://dx.doi.org/10.3109/15563650.2012.670244.

@article{1088212,
   author = {Pelclová, Daniela and Sklenský, Martin and Janíček, Pavel and Lach, Karel},
   article_location = {NEW YORK},
   article_number = {4},
   doi = {http://dx.doi.org/10.3109/15563650.2012.670244},
   keywords = {Cobalt; Hip prosthesis; Cardiomyopathy; Hypothyreosis; Hearing loss; DMPS; Chromium},
   language = {eng},
   issn = {1556-3650},
   journal = {CLINICAL TOXICOLOGY},
   title = {Severe cobalt intoxication following hip replacement revision: Clinical features and outcome},
   volume = {50},
   year = {2012}
}

TY  - JOUR
ID  - 1088212
AU  - Pelclová, Daniela - Sklenský, Martin - Janíček, Pavel - Lach, Karel
PY  - 2012
TI  - Severe cobalt intoxication following hip replacement revision: Clinical features and outcome
JF  - CLINICAL TOXICOLOGY
VL  - 50
IS  - 4
SP  - 262-265
EP  - 262-265
PB  - INFORMA HEALTHCARE
SN  - 15563650
KW  - Cobalt
KW  - Hip prosthesis
KW  - Cardiomyopathy
KW  - Hypothyreosis
KW  - Hearing loss
KW  - DMPS
KW  - Chromium
N2  - Context. Cobalt intoxication has become more frequent due to the wide use of metal hip implants. Case details. A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved. Conclusion. We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit.
ER  -

PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH. Severe cobalt intoxication following hip replacement revision: Clinical features and outcome. \textit{CLINICAL TOXICOLOGY}. NEW YORK: INFORMA HEALTHCARE, 2012, vol.~50, No~4, p.~262-265. ISSN~1556-3650. Available from: https://dx.doi.org/10.3109/15563650.2012.670244.

Detailed Information on Publication Record