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@article{1088212, author = {Pelclová, Daniela and Sklenský, Martin and Janíček, Pavel and Lach, Karel}, article_location = {NEW YORK}, article_number = {4}, doi = {http://dx.doi.org/10.3109/15563650.2012.670244}, keywords = {Cobalt; Hip prosthesis; Cardiomyopathy; Hypothyreosis; Hearing loss; DMPS; Chromium}, language = {eng}, issn = {1556-3650}, journal = {CLINICAL TOXICOLOGY}, title = {Severe cobalt intoxication following hip replacement revision: Clinical features and outcome}, volume = {50}, year = {2012} }
TY - JOUR ID - 1088212 AU - Pelclová, Daniela - Sklenský, Martin - Janíček, Pavel - Lach, Karel PY - 2012 TI - Severe cobalt intoxication following hip replacement revision: Clinical features and outcome JF - CLINICAL TOXICOLOGY VL - 50 IS - 4 SP - 262-265 EP - 262-265 PB - INFORMA HEALTHCARE SN - 15563650 KW - Cobalt KW - Hip prosthesis KW - Cardiomyopathy KW - Hypothyreosis KW - Hearing loss KW - DMPS KW - Chromium N2 - Context. Cobalt intoxication has become more frequent due to the wide use of metal hip implants. Case details. A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved. Conclusion. We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit. ER -
PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH. Severe cobalt intoxication following hip replacement revision: Clinical features and outcome. \textit{CLINICAL TOXICOLOGY}. NEW YORK: INFORMA HEALTHCARE, 2012, vol.~50, No~4, p.~262-265. ISSN~1556-3650. Available from: https://dx.doi.org/10.3109/15563650.2012.670244.
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