PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH. Severe cobalt intoxication following hip replacement revision: Clinical features and outcome. CLINICAL TOXICOLOGY. NEW YORK: INFORMA HEALTHCARE, 2012, vol. 50, No 4, p. 262-265. ISSN 1556-3650. Available from: https://dx.doi.org/10.3109/15563650.2012.670244.
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Basic information
Original name Severe cobalt intoxication following hip replacement revision: Clinical features and outcome
Authors PELCLOVÁ, Daniela, Martin SKLENSKÝ, Pavel JANÍČEK and Karel LACH.
Edition CLINICAL TOXICOLOGY, NEW YORK, INFORMA HEALTHCARE, 2012, 1556-3650.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30211 Orthopaedics
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.592
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3109/15563650.2012.670244
UT WoS 000302024600006
Keywords in English Cobalt; Hip prosthesis; Cardiomyopathy; Hypothyreosis; Hearing loss; DMPS; Chromium
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 23/4/2014 14:10.
Abstract
Context. Cobalt intoxication has become more frequent due to the wide use of metal hip implants. Case details. A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved. Conclusion. We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit.
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