ŠPONER, Jiří, Michal OTYEPKA, Pavel BANÁŠ, Kamila RÉBLOVÁ and Nils WALTER. Molecular Dynamics Simulations of RNA Molecules. In Tamar Schlick. Innovations in Biomolecular Modeling and Simulations. 1. vydání. Cambridge: The Royal Society of Chemistry, 2012, p. 129-155. Volume 2. ISBN 978-1-84973-462-2.
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Basic information
Original name Molecular Dynamics Simulations of RNA Molecules
Authors ŠPONER, Jiří, Michal OTYEPKA, Pavel BANÁŠ, Kamila RÉBLOVÁ and Nils WALTER.
Edition 1. vydání. Cambridge, Innovations in Biomolecular Modeling and Simulations, p. 129-155, 27 pp. Volume 2, 2012.
Publisher The Royal Society of Chemistry
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 10610 Biophysics
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
Organization unit Central European Institute of Technology
ISBN 978-1-84973-462-2
Keywords (in Czech) Molecular dynamics, RNA, RNP
Tags ne MU
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 6/4/2016 14:04.
Abstract
The central role of RNA in numerous biological processes including translation, protein localization, gene regulation, RNA processing, and viral replication calls for a detailed understanding of RNA function, structure, and conformational dynamics. Accompanying and enhancing our increasing appreciation of RNA is the rapidly expanding availability of high-resolution structures of RNAs and RNA-protein (RNP) complexes. These atomic resolution snapshots provide detailed rationalization for existing biochemical data. However, biological function depends on the dynamic evolution of structures along functional pathways. A complete understanding of the relevant structural dynamics exhibited by RNA requires monitoring timescales from picoseconds to hours through the application of a correspondingly broad range of techniques, with careful consideration given to the scope and limitation of each approach.
Links
LC06030, research and development projectName: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
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