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@article{1089789,
author = {Heck, Julia E. and Moore, Lee E. and Lee, YuanandChin A. and McKay, James D. and Hung, Rayjean J. and Karami, Sara and Gaborieau, Valérie and SzeszeniaandDabrowska, Neonila and Zaridze, David G. and Mukeriya, Anush and Mates, Dana and Foretová, Lenka and Janout, Vladimir and Kollárová, Helena and Bencko, Vladimir and Rothman, Nathaniel and Brennan, Paul and Chow, WongandHo and Boffetta, Paolo},
doi = {http://dx.doi.org/10.3389/fonc.2012.00016},
keywords = {renal cell cancer, epidemiology, NAT1, NAT2, CYP, NQO1, mEH, COMT},
language = {eng},
issn = {2234-943X},
journal = {Frontiers in Oncology},
title = {Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study},
year = {2012}
}
TY - JOUR
ID - 1089789
AU - Heck, Julia E. - Moore, Lee E. - Lee, Yuan-Chin A. - McKay, James D. - Hung, Rayjean J. - Karami, Sara - Gaborieau, Valérie - Szeszenia-Dabrowska, Neonila - Zaridze, David G. - Mukeriya, Anush - Mates, Dana - Foretová, Lenka - Janout, Vladimir - Kollárová, Helena - Bencko, Vladimir - Rothman, Nathaniel - Brennan, Paul - Chow, Wong-Ho - Boffetta, Paolo
PY - 2012
TI - Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study
JF - Frontiers in Oncology
SN - 2234943X
KW - renal cell cancer, epidemiology, NAT1, NAT2, CYP, NQO1, mEH, COMT
N2 - Background: The countries of Central and Eastern Europe have among the highest worldwide rates of renal cell cancer (RCC). Few studies have examined whether genetic variation in xenobiotic metabolic pathway genes may modify risk for this cancer. Methods: The Central and Eastern Europe Renal Cell Cancer study was a hospital-based case–control study conducted between 1998 and 2003 across seven centers in Central and Eastern Europe. Detailed data were collected from 874 cases and 2053 controls on demographics, work history, and occupational exposure to chemical agents. Genes [cytochrome P-450 family, N-acetyltransferases, NAD(P)H:quinone oxidoreductase I (NQO1), microsomal epoxide hydrolase (mEH), catechol-O-methyltransferase (COMT), uridine diphosphate-glucuronosyltransferase (UGT)] were selected for the present analysis based on their putative role in xenobiotic metabolism. Haplotypes were calculated using fastPhase. Odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for country of residence, age, sex, smoking, alcohol intake, obesity, and hypertension. Results: We observed an increased risk of RCC with one SNP. After adjustment for multiple comparisons it did not remain significant. Neither NAT1 nor NAT2 slow acetylation was associated with disease. Conclusion: We observed no association between this pathway and renal cell cancer.
ER -
HECK, Julia E., Lee E. MOORE, Yuan-Chin A. LEE, James D. MCKAY, Rayjean J. HUNG, Sara KARAMI, Valérie GABORIEAU, Neonila SZESZENIA-DABROWSKA, David G. ZARIDZE, Anush MUKERIYA, Dana MATES, Lenka FORETOVÁ, Vladimir JANOUT, Helena KOLLÁROVÁ, Vladimir BENCKO, Nathaniel ROTHMAN, Paul BRENNAN, Wong-Ho CHOW and Paolo BOFFETTA. Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study. \textit{Frontiers in Oncology}. 2012. ISSN~2234-943X. Available from: https://dx.doi.org/10.3389/fonc.2012.00016.
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