Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy?

REKTOR, Ivan, Robert KUBA, Milan BRÁZDIL and Jan CHRASTINA. Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy? EPILEPSY & BEHAVIOR. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012, vol. 25, No 1, p. 56-59. ISSN 1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2012.04.125.

Basic information

• Original name: Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy?
• Authors: REKTOR, Ivan (203 Czech Republic, guarantor, belonging to the institution), Robert KUBA (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Jan CHRASTINA (203 Czech Republic, belonging to the institution).
• Edition: EPILEPSY & BEHAVIOR, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012, 1525-5050.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.844
• RIV identification code: RIV/00216224:14740/12:00064334
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.yebeh.2012.04.125
• UT WoS: 000308999500011
• Keywords in English: Basal ganglia; Temporal lobe; Epilepsy
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

There is substantial evidence in the literature that the basal ganglia (BG), namely the striatum and pallidum, are involved in temporal lobe epilepsy (TLE). The BG are probably not involved in elaborating clinical seizures, as they do not produce specific epileptiform activity and there is no evident change in the electrical activity in the BG immediately after seizure onset. The data we obtained by direct ictal recording in the BG [1,2], as well as a large body of experimental and clinical evidence reported by other groups, suggest an inhibitory role of the BG during temporal lobe seizures. The BG may have a remote influence on cortical oscillatory processes related to control of epileptic seizures via their feedback pathways to the cortex. (C) 2012 Elsevier Inc. All rights reserved.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology