Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ, Sabina TELECKÁ, Michal DUFEK and Irena REKTOROVÁ. Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. Movement Disorders. Hoboken, USA: WILEY-BLACKWELL, 2012, vol. 27, No 9, p. 1168-1172. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.25066.

Basic information

• Original name: Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease
• Authors: REKTOR, Ivan (203 Czech Republic, guarantor, belonging to the institution), David GOLDEMUND (203 Czech Republic, belonging to the institution), Petr BEDNAŘÍK (203 Czech Republic, belonging to the institution), Kateřina SHEARDOVÁ (203 Czech Republic, belonging to the institution), Zuzana MICHÁLKOVÁ (203 Czech Republic, belonging to the institution), Sabina TELECKÁ (203 Czech Republic, belonging to the institution), Michal DUFEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution).
• Edition: Movement Disorders, Hoboken, USA, WILEY-BLACKWELL, 2012, 0885-3185.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.558
• RIV identification code: RIV/00216224:14740/12:00064335
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1002/mds.25066
• UT WoS: 000307387400030
• Keywords in English: cerebrovascular disease; Parkinson's disease; MRI; ultrasound
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. Results: US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. (C) 2012 Movement Disorder Society

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.