Impairment of Brain Vessels May Contribute to Mortality in
Patients With Parkinson's Disease

J 2012

Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ et. al.

Basic information

Original name

Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease

Authors

REKTOR, Ivan (203 Czech Republic, guarantor, belonging to the institution), David GOLDEMUND (203 Czech Republic, belonging to the institution), Petr BEDNAŘÍK (203 Czech Republic, belonging to the institution), Kateřina SHEARDOVÁ (203 Czech Republic, belonging to the institution), Zuzana MICHÁLKOVÁ (203 Czech Republic, belonging to the institution), Sabina TELECKÁ (203 Czech Republic, belonging to the institution), Michal DUFEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)

Edition

Movement Disorders, Hoboken, USA, WILEY-BLACKWELL, 2012, 0885-3185

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.558

RIV identification code

RIV/00216224:14740/12:00064335

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1002/mds.25066

UT WoS

000307387400030

Keywords in English

cerebrovascular disease; Parkinson's disease; MRI; ultrasound

Abstract

V originále

Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. Results: US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. (C) 2012 Movement Disorder Society

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ, Sabina TELECKÁ, Michal DUFEK and Irena REKTOROVÁ. Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. Movement Disorders. Hoboken, USA: WILEY-BLACKWELL, 2012, vol. 27, No 9, p. 1168-1172. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.25066.

@article{1090829,
   author = {Rektor, Ivan and Goldemund, David and Bednařík, Petr and Sheardová, Kateřina and Michálková, Zuzana and Telecká, Sabina and Dufek, Michal and Rektorová, Irena},
   article_location = {Hoboken, USA},
   article_number = {9},
   doi = {http://dx.doi.org/10.1002/mds.25066},
   keywords = {cerebrovascular disease; Parkinson's disease; MRI; ultrasound},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22692677},
   volume = {27},
   year = {2012}
}

TY  - JOUR
ID  - 1090829
AU  - Rektor, Ivan - Goldemund, David - Bednařík, Petr - Sheardová, Kateřina - Michálková, Zuzana - Telecká, Sabina - Dufek, Michal - Rektorová, Irena
PY  - 2012
TI  - Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease
JF  - Movement Disorders
VL  - 27
IS  - 9
SP  - 1168-1172
EP  - 1168-1172
PB  - WILEY-BLACKWELL
SN  - 08853185
KW  - cerebrovascular disease
KW  - Parkinson's disease
KW  - MRI
KW  - ultrasound
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22692677
L2  - http://www.ncbi.nlm.nih.gov/pubmed/22692677
N2  - Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. Results: US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. (C) 2012 Movement Disorder Society
ER  -

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ, Sabina TELECKÁ, Michal DUFEK and Irena REKTOROVÁ. Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. \textit{Movement Disorders}. Hoboken, USA: WILEY-BLACKWELL, 2012, vol.~27, No~9, p.~1168-1172. ISSN~0885-3185. Available from: https://dx.doi.org/10.1002/mds.25066.

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