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@article{1090829,
author = {Rektor, Ivan and Goldemund, David and Bednařík, Petr and Sheardová, Kateřina and Michálková, Zuzana and Telecká, Sabina and Dufek, Michal and Rektorová, Irena},
article_location = {Hoboken, USA},
article_number = {9},
doi = {http://dx.doi.org/10.1002/mds.25066},
keywords = {cerebrovascular disease; Parkinson's disease; MRI; ultrasound},
language = {eng},
issn = {0885-3185},
journal = {Movement Disorders},
title = {Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22692677},
volume = {27},
year = {2012}
}
TY - JOUR
ID - 1090829
AU - Rektor, Ivan - Goldemund, David - Bednařík, Petr - Sheardová, Kateřina - Michálková, Zuzana - Telecká, Sabina - Dufek, Michal - Rektorová, Irena
PY - 2012
TI - Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease
JF - Movement Disorders
VL - 27
IS - 9
SP - 1168-1172
EP - 1168-1172
PB - WILEY-BLACKWELL
SN - 08853185
KW - cerebrovascular disease
KW - Parkinson's disease
KW - MRI
KW - ultrasound
UR - http://www.ncbi.nlm.nih.gov/pubmed/22692677
L2 - http://www.ncbi.nlm.nih.gov/pubmed/22692677
N2 - Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. Results: US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. (C) 2012 Movement Disorder Society
ER -
REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ, Sabina TELECKÁ, Michal DUFEK a Irena REKTOROVÁ. Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. \textit{Movement Disorders}. Hoboken, USA: WILEY-BLACKWELL, roč.~27, č.~9, s.~1168-1172. ISSN~0885-3185. doi:10.1002/mds.25066. 2012.
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