PAŘENICA, Jiří, Jindřich ŠPINAR, Jiří VÍTOVEC, Petr WIDIMSKY, Ales LINHART, Marian FEDORCO, Jan VACLAVIK, Roman MIKLÍK, Marián FELŠŐCI, Kateřina HOŘÁKOVÁ, Cestmir CIHALIK, Filip MALEK, Lenka ŠPINAROVÁ, Jan BĚLOHLÁVEK, Jiří KETTNER, Kamil ZEMAN, Ladislav DUŠEK and Jiří JARKOVSKÝ. Long-term survival following acute heart failure: The Acute Heart Failure Database Main registry (AHEAD Main). European Journal of Internal Medicine. AMSTERDAM: ELSEVIER SCIENCE BV, 2013, vol. 24, No 2, p. 151-160. ISSN 0953-6205. doi:10.1016/j.ejim.2012.11.005.
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Basic information
Original name Long-term survival following acute heart failure: The Acute Heart Failure Database Main registry (AHEAD Main)
Authors PAŘENICA, Jiří (203 Czech Republic, guarantor, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Jiří VÍTOVEC (203 Czech Republic, belonging to the institution), Petr WIDIMSKY (203 Czech Republic), Ales LINHART (203 Czech Republic), Marian FEDORCO (203 Czech Republic), Jan VACLAVIK (203 Czech Republic), Roman MIKLÍK (203 Czech Republic), Marián FELŠŐCI (703 Slovakia), Kateřina HOŘÁKOVÁ (203 Czech Republic, belonging to the institution), Cestmir CIHALIK (203 Czech Republic), Filip MALEK (203 Czech Republic), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Jan BĚLOHLÁVEK (203 Czech Republic), Jiří KETTNER (203 Czech Republic), Kamil ZEMAN (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution).
Edition European Journal of Internal Medicine, AMSTERDAM, ELSEVIER SCIENCE BV, 2013, 0953-6205.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.300
RIV identification code RIV/00216224:14110/13:00067905
Organization unit Faculty of Medicine
UT WoS 000314786000018
Keywords in English Acute heart failure; AHEAD; Prognosis
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 4. 2. 2014 16:20.
Background: The in-hospital mortality of patients with acute heart failure (AHF) is reported to be 12.7% and mortality on day 30 after admission 17.2%. Less information is known about the long-term prognosis of those patients discharged after hospitalization. As such, the aim of this study was to investigate long-term survival in a cohort of patients who had been hospitalized for AHF and then discharged. Methods: The AHEAD Main registry includes 4153 patients hospitalized for AHF in 7 different medical centers, each with its own cathlab, in the Czech Republic. Patient survival rates were evaluated in 3438 patients who had survived to day 30 after admission, and were used as a measurement of long-term survival. Results: The most common etiologies were acute coronary syndrome (32.3%) and chronic ischemic heart disease (20.1%). The survival rate after day 30 following admission was 79.7% after 1 year and 64.5% after 3 years. No statistically significant difference in syndromes was found in survival after day 30. Independent predictors of a worse prognosis were defined as follows: age > 70 years, comorbidities, severe left ventricular systolic dysfunction, valvular disease or ACS as an etiology of AHF. A better prognosis was defined for de-novo AHF patients, and those who were taking ACE inhibitors at the time of discharge. In a sub-analysis, high levels of natriuretic peptides were the most powerful predictors of high-risk, long-term mortality. Conclusion: The AHEAD Main registry provides up-to-date information on the long-term prognosis of patients hospitalized with AHF. The 3-year survival of patients following day 30 of admission was 64.5%. Higher age, LV dysfunction, comorbidities and high levels of natriuretic peptides were the most powerful predictors of worse prognosis in long-term survival.
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