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@article{1091977,
author = {Kaucká, Markéta and Plevová, Karla and Pavlová, Šárka and Janovská, Pavlína and Shaik, Archana and Verner, Jan and Procházková, Jiřina and Krejčí, Pavel and Kotašková, Jana and Ovesná, Petra and Tichý, Boris and Brychtová, Yvona and Doubek, Michael and Kozubík, Alois and Mayer, Jiří and Pospíšilová, Šárka and Bryja, Vítězslav},
article_location = {USA},
article_number = {5},
doi = {http://dx.doi.org/10.1158/0008-5472.CAN-12-1752},
keywords = {Planar cell polarity; Wnt; casein kinase 1; B-CLL},
language = {eng},
issn = {0008-5472},
journal = {Cancer Research},
title = {The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23338609},
volume = {73},
year = {2013}
}
TY - JOUR
ID - 1091977
AU - Kaucká, Markéta - Plevová, Karla - Pavlová, Šárka - Janovská, Pavlína - Shaik, Archana - Verner, Jan - Procházková, Jiřina - Krejčí, Pavel - Kotašková, Jana - Ovesná, Petra - Tichý, Boris - Brychtová, Yvona - Doubek, Michael - Kozubík, Alois - Mayer, Jiří - Pospíšilová, Šárka - Bryja, Vítězslav
PY - 2013
TI - The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
JF - Cancer Research
VL - 73
IS - 5
SP - 1491-1501
EP - 1491-1501
PB - American Association for Cancer Research
SN - 00085472
KW - Planar cell polarity
KW - Wnt
KW - casein kinase 1
KW - B-CLL
UR - http://www.ncbi.nlm.nih.gov/pubmed/23338609
N2 - The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.
ER -
KAUCKÁ, Markéta, Karla PLEVOVÁ, Šárka PAVLOVÁ, Pavlína JANOVSKÁ, Archana SHAIK, Jan VERNER, Jiřina PROCHÁZKOVÁ, Pavel KREJČÍ, Jana KOTAŠKOVÁ, Petra OVESNÁ, Boris TICHÝ, Yvona BRYCHTOVÁ, Michael DOUBEK, Alois KOZUBÍK, Jiří MAYER, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration. \textit{Cancer Research}. USA: American Association for Cancer Research, 2013, vol.~73, No~5, p.~1491-1501. ISSN~0008-5472. Available from: https://dx.doi.org/10.1158/0008-5472.CAN-12-1752.
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