J 2013

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

KAUCKÁ, Markéta, Karla PLEVOVÁ, Šárka PAVLOVÁ, Pavlína JANOVSKÁ, Archana SHAIK et. al.

Basic information

Original name

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

Authors

KAUCKÁ, Markéta (203 Czech Republic, belonging to the institution), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Šárka PAVLOVÁ (203 Czech Republic, belonging to the institution), Pavlína JANOVSKÁ (203 Czech Republic, belonging to the institution), Archana SHAIK (356 India), Jan VERNER (203 Czech Republic, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), Jana KOTAŠKOVÁ (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution), Boris TICHÝ (203 Czech Republic, belonging to the institution), Yvona BRYCHTOVÁ (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution) and Vítězslav BRYJA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cancer Research, USA, American Association for Cancer Research, 2013, 0008-5472

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 9.284

RIV identification code

RIV/00216224:14310/13:00065763

Organization unit

Faculty of Science

DOI

UT WoS

000315741500006

Keywords in English

Planar cell polarity; Wnt; casein kinase 1; B-CLL

Tags

Tags

International impact, Reviewed
Změněno: 25/4/2014 14:50, Ing. Zdeňka Rašková

Abstract

V originále

The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.

Links

CZ.1.05/1.1.00/02.0068, interní kód MU
Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC)
Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence
CZ.1.07/2.3.00/20.0045, interní kód MU
Name: SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny (Acronym: SuPReMMe)
Investor: Ministry of Education, Youth and Sports of the CR, 2.3 Human resources in research and development
EE2.3.20.0180, research and development project
Name: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny
GAP301/11/0747, research and development project
Name: Molekulární mechanismy nekanonické Wnt signalizace v leukémii
Investor: Czech Science Foundation
GAP305/11/0752, research and development project
Name: Molekulární základy FGFR3 signalingu v kostní dysplázii
Investor: Czech Science Foundation
GD204/09/H058, research and development project
Name: Mezibuněčná signalizace ve vývoji organismu a vzniku onemocnění
Investor: Czech Science Foundation, Intercellular signalling in development and disease
MSM0021622430, plan (intention)
Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
MUNI/A/0784/2011, interní kód MU
Name: Nové diagnostické a klinické přístupy v onkologii (Acronym: NoDiKliPO)
Investor: Masaryk University, Category A
MUNI/E/0128/2009, interní kód MU
Name: Úloha komponent Wnt/PCP dráhy v patogenezi B lymfocytární chronické leukémie
Investor: Masaryk University, Category E - development project + specific research
NT11217, research and development project
Name: Úloha nekanonické Wnt signalizace v molekulární patogenezi chronické lymfocytární leukémie
NT13493, research and development project
Name: Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie

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