The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the ...
KAUCKÁ, Markéta, Karla PLEVOVÁ, Šárka PAVLOVÁ, Pavlína JANOVSKÁ, Archana SHAIK, Jan VERNER, Jiřina PROCHÁZKOVÁ, Pavel KREJČÍ, Jana KOTAŠKOVÁ, Petra OVESNÁ, Boris TICHÝ, Yvona BRYCHTOVÁ, Michael DOUBEK, Alois KOZUBÍK, Jiří MAYER, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration. Cancer Research. USA: American Association for Cancer Research, 2013, vol. 73, No 5, p. 1491-1501. ISSN 0008-5472. Available from: https://dx.doi.org/10.1158/0008-5472.CAN-12-1752. |
Other formats:
BibTeX
LaTeX
RIS
|
Basic information | |
---|---|
Original name | The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration |
Authors | KAUCKÁ, Markéta (203 Czech Republic, belonging to the institution), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Šárka PAVLOVÁ (203 Czech Republic, belonging to the institution), Pavlína JANOVSKÁ (203 Czech Republic, belonging to the institution), Archana SHAIK (356 India), Jan VERNER (203 Czech Republic, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), Jana KOTAŠKOVÁ (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution), Boris TICHÝ (203 Czech Republic, belonging to the institution), Yvona BRYCHTOVÁ (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution) and Vítězslav BRYJA (203 Czech Republic, guarantor, belonging to the institution). |
Edition | Cancer Research, USA, American Association for Cancer Research, 2013, 0008-5472. |
Other information | |
---|---|
Original language | English |
Type of outcome | Article in a journal |
Field of Study | 30105 Physiology |
Country of publisher | United States of America |
Confidentiality degree | is not subject to a state or trade secret |
WWW | URL |
Impact factor | Impact factor: 9.284 |
RIV identification code | RIV/00216224:14310/13:00065763 |
Organization unit | Faculty of Science |
Doi | http://dx.doi.org/10.1158/0008-5472.CAN-12-1752 |
UT WoS | 000315741500006 |
Keywords in English | Planar cell polarity; Wnt; casein kinase 1; B-CLL |
Tags | AKR, podil, ZR |
Tags | International impact, Reviewed |
Changed by | Changed by: Ing. Zdeňka Rašková, učo 140529. Changed: 25/4/2014 14:50. |
Abstract |
---|
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment. |
Links | |
---|---|
CZ.1.05/1.1.00/02.0068, interní kód MU | Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC) |
Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence | |
CZ.1.07/2.3.00/20.0045, interní kód MU | Name: SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny (Acronym: SuPReMMe) |
Investor: Ministry of Education, Youth and Sports of the CR, 2.3 Human resources in research and development | |
EE2.3.20.0180, research and development project | Name: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny |
GAP301/11/0747, research and development project | Name: Molekulární mechanismy nekanonické Wnt signalizace v leukémii |
Investor: Czech Science Foundation | |
GAP305/11/0752, research and development project | Name: Molekulární základy FGFR3 signalingu v kostní dysplázii |
Investor: Czech Science Foundation | |
GD204/09/H058, research and development project | Name: Mezibuněčná signalizace ve vývoji organismu a vzniku onemocnění |
Investor: Czech Science Foundation, Intercellular signalling in development and disease | |
MSM0021622430, plan (intention) | Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie |
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies | |
MUNI/A/0784/2011, interní kód MU | Name: Nové diagnostické a klinické přístupy v onkologii (Acronym: NoDiKliPO) |
Investor: Masaryk University, Category A | |
MUNI/E/0128/2009, interní kód MU | Name: Úloha komponent Wnt/PCP dráhy v patogenezi B lymfocytární chronické leukémie |
Investor: Masaryk University, Category E - development project + specific research | |
NT11217, research and development project | Name: Úloha nekanonické Wnt signalizace v molekulární patogenezi chronické lymfocytární leukémie |
NT13493, research and development project | Name: Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie |
PrintDisplayed: 13/10/2024 00:19