ŠTOURAČ, Petr, Ivo KŘIKAVA, Judita SEIDLOVÁ, Eva STRAŽEVSKÁ, Martin HUSER, Lukáš HRUBAN, Petr JANKŮ and Roman GÁL. Sugammadex in a parturient with myotonic dystrophy. British Journal of Anaesthesia. OXFORD: Oxford University Press, 2013, vol. 110, No 4, p. 657-658. ISSN 0007-0912. Available from: https://dx.doi.org/10.1093/bja/aet037.
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Basic information
Original name Sugammadex in a parturient with myotonic dystrophy
Name in Czech Použití sugammadexu u rodičky s myotonickou dystrofií
Authors ŠTOURAČ, Petr (203 Czech Republic, guarantor, belonging to the institution), Ivo KŘIKAVA (203 Czech Republic, belonging to the institution), Judita SEIDLOVÁ (203 Czech Republic), Eva STRAŽEVSKÁ (203 Czech Republic, belonging to the institution), Martin HUSER (203 Czech Republic, belonging to the institution), Lukáš HRUBAN (203 Czech Republic, belonging to the institution), Petr JANKŮ (203 Czech Republic, belonging to the institution) and Roman GÁL (203 Czech Republic, belonging to the institution).
Edition British Journal of Anaesthesia, OXFORD, Oxford University Press, 2013, 0007-0912.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30214 Obstetrics and gynaecology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.354
RIV identification code RIV/00216224:14110/13:00067924
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/bja/aet037
UT WoS 000316700600024
Keywords (in Czech) sugammadex; myotonická dystrofie; císařský řez; celková anestezie
Keywords in English sugammadex; myotonic dystrophy; Caesarean Section; General Anaesthesia
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 26/4/2014 11:36.
Abstract
Myotonic dystrophy is a chronic, slowly progressing, highly variable, inherited multisystemic disease. It is characterized by wasting of the muscles (muscular dystrophy), cataracts, heart conduction abnormalities, endocrine changes, slow gastric and bowel emptying, and myotonia. Patients with myotonic dystrophy show myotonic responses to succinylcholine and neostigmine, and increased sensitivity to non-depolarising muscle relaxants. We report two cases of a parturient with myotonic dystrophy scheduled for Caesarean Section under general anaesthesia, once in 2009 and once in 2011. Muscle relaxant anaesthetic management in 2009 consisted of rocuronium and waiting for spontaneous neuromuscular blockade recovery with arteficial ventilation in the intensive care unit for 2 hours and 30 minutes postoperatively. In 2011, the same patient was indicated for the selective binding agent sugammadex ( 4 mg kg-1) to actively reverse deep neuromuscular blockade at the end of surgery. Train of Four ratio 0.9 was achieved in 2 minutes. There was no exacerbation of myotonia and no recurrence of muscle relaxation perioperatively in either case. These two obstetric cases provide evidence for the benefits of sugammadex in patients with myotonic dystrophy. We also suggest that it could be used in other patients with neuromuscular diseases.
Abstract (in Czech)
Přinášíme dvě kazuistiky průběhu ukončení těhotenství císařským řezem u rodičky, u které byla diagnostikována Myotonia Congenita Levior. Poukazujeme zejména na rozdílný průběh zotavení z nervosvalové blokády užitím aktivní reverze nedepolarizujícího bloku sugammadexem.
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