Detailed Information on Publication Record
2012
The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson's disease
SROVNALOVÁ, Hana, Radek MAREČEK, Radka KUBÍKOVÁ and Irena REKTOROVÁBasic information
Original name
The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson's disease
Authors
SROVNALOVÁ, Hana (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Radka KUBÍKOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Experimental Brain Research, NEW YORK, Springer Verlag, 2012, 0014-4819
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.221
RIV identification code
RIV/00216224:14740/12:00064604
Organization unit
Central European Institute of Technology
UT WoS
000310075100008
Keywords in English
Parkinson's disease; Repetitive transcranial magnetic stimulation; Tower of London task; Executive function; Dorsolateral prefrontal cortex
Tags
International impact, Reviewed
Změněno: 23/4/2013 09:13, Olga Křížová
Abstract
V originále
We studied whether one session of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over either the right or left dorsolateral prefrontal cortex would induce any measurable changes in the Tower of London spatial planning task performance in patients with Parkinson's disease (PD). Ten patients with PD (with no dementia and/or depression) entered the randomized, sham-stimulation-controlled study with a crossover design. Active and placebo rTMS were applied over either the left or the right dorsolateral prefrontal cortex (in four separate sessions) in each patient. The order of sessions was randomized. The Tower of London task was performed prior to and immediately after each appropriate session. The "total problem-solving time" was our outcome measure. Only active rTMS of the right dorsolateral prefrontal cortex induced significant enhancement of the total problem-solving time, p = 0.038. Stimulation of the left prefrontal cortex or sham stimulations induced no significant effects. Only rTMS applied over the right dorsolateral prefrontal cortex induced positive changes in the spatial planning task performance in PD, which further supports the results of functional imaging studies indicating the causal engagement of the right-sided hemispheric structures in solving the task in this patient population.
Links
| ED1.1.00/02.0068, research and development project |
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