J 2012

Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK and Michal MIKL

Basic information

Original name

Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia

Authors

REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Lenka KRAJČOVIČOVÁ (703 Slovakia, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Michal MIKL (203 Czech Republic, belonging to the institution)

Edition

Neurodegenerative Diseases, Basel, Switzerland, Karger, 2012, 1660-2854

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.410

RIV identification code

RIV/00216224:14740/12:00064605

Organization unit

Central European Institute of Technology

DOI

UT WoS

000303660600049

Keywords in English

Default mode network; Extrastriate visual resting state network; Parkinson's disease dementia; Functional connectivity

Tags

Tags

International impact, Reviewed
Změněno: 2/4/2013 08:51, Olga Křížová

Abstract

V originále

Aims: Using fMRI, we evaluated the default mode network (DMN) and the extrastriate visual resting state network (ESV-RSN) in 14 patients with Parkinson's disease dementia (PDD) as compared with 18 patients with Parkinson's disease (PD) without dementia and 18 healthy controls (HC). Methods: We analyzed the seed-based functional connectivity of both resting state data and deactivations during a visual complex scene-encoding task. Results: Using the posterior cingulate cortex/precuneus as a seed for the DMN analysis, we observed significant decreases of connectivity in the right inferior frontal gyrus in PDD as compared to PD and HC. Using the caudate nucleus as a seed for the ESV-RSN analysis, we found significant decreases of connectivity in the left and right inferior occipital gyrus in PDD as compared to HC. Conclusion: Differences in functional connectivity patterns between PDD and PD/HC were observed in areas known to be engaged in stimulus-driven reorienting of attention and in visual processing. Copyright (C) 2012 S. Karger AG, Basel

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.