Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK and Michal MIKL. Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia. Neurodegenerative Diseases. Basel, Switzerland: Karger, vol. 10, 1-4, p. 232-237. ISSN 1660-2854. doi:10.1159/000334765. 2012.

Basic information

• Original name: Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia
• Authors: REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Lenka KRAJČOVIČOVÁ (703 Slovakia, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Michal MIKL (203 Czech Republic, belonging to the institution).
• Edition: Neurodegenerative Diseases, Basel, Switzerland, Karger, 2012, 1660-2854.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.410
• RIV identification code: RIV/00216224:14740/12:00064605
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1159/000334765
• UT WoS: 000303660600049
• Keywords in English: Default mode network; Extrastriate visual resting state network; Parkinson's disease dementia; Functional connectivity
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Aims: Using fMRI, we evaluated the default mode network (DMN) and the extrastriate visual resting state network (ESV-RSN) in 14 patients with Parkinson's disease dementia (PDD) as compared with 18 patients with Parkinson's disease (PD) without dementia and 18 healthy controls (HC). Methods: We analyzed the seed-based functional connectivity of both resting state data and deactivations during a visual complex scene-encoding task. Results: Using the posterior cingulate cortex/precuneus as a seed for the DMN analysis, we observed significant decreases of connectivity in the right inferior frontal gyrus in PDD as compared to PD and HC. Using the caudate nucleus as a seed for the ESV-RSN analysis, we found significant decreases of connectivity in the left and right inferior occipital gyrus in PDD as compared to HC. Conclusion: Differences in functional connectivity patterns between PDD and PD/HC were observed in areas known to be engaged in stimulus-driven reorienting of attention and in visual processing. Copyright (C) 2012 S. Karger AG, Basel

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.