Další formáty:
BibTeX
LaTeX
RIS
@article{1094322,
author = {Krajčovičová, Lenka and Mikl, Michal and Mareček, Radek and Rektorová, Irena},
article_location = {Vídeň},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s00702-011-0723-5},
keywords = {Parkinson's disease; Default mode network; Deactivation; Functional connectivity; Hippocampus; Levodopa},
language = {eng},
issn = {0300-9564},
journal = {Journal of Neural Transmission},
title = {The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22002597},
volume = {119},
year = {2012}
}
TY - JOUR
ID - 1094322
AU - Krajčovičová, Lenka - Mikl, Michal - Mareček, Radek - Rektorová, Irena
PY - 2012
TI - The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent
JF - Journal of Neural Transmission
VL - 119
IS - 4
SP - 443-454
EP - 443-454
PB - SPRINGER WIEN
SN - 03009564
KW - Parkinson's disease
KW - Default mode network
KW - Deactivation
KW - Functional connectivity
KW - Hippocampus
KW - Levodopa
UR - http://www.ncbi.nlm.nih.gov/pubmed/22002597
L2 - http://www.ncbi.nlm.nih.gov/pubmed/22002597
N2 - Disturbances in the default mode network (DMN) have been described in many neurological and psychiatric disorders including Parkinson's disease (PD). The DMN is characterized by basal activity that increases during rest or passive visual fixation and decreases ("deactivates'') during cognitive tasks. The network is believed to be involved in cognitive processes. We examined the DMN in PD patients on dopaminergic medication with normal cognitive performance compared to age-and gender-matched healthy controls (HC) using fMRI and three methodological procedures: independent component analysis of resting-state data, analysis of deactivation during a complex visual scene-encoding task, and seed-based functional connectivity analysis. In the PD group, we also studied the effect of dopaminergic medication on the DMN integrity. We did not find any difference between the PD and HC groups in the DMN, but using the daily levodopa equivalent dose as a covariate, we observed an enhanced functional connectivity of the DMN in the posterior cingulate cortex and decreased activation in the left parahippocampal gyrus during the cognitive task. We conclude that dopaminergic therapy has a specific effect on both the DMN integrity and task-related brain activations in cognitively unimpaired PD patients, and these effects seem to be dose-dependent.
ER -
KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK a Irena REKTOROVÁ. The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent. \textit{Journal of Neural Transmission}. Vídeň: SPRINGER WIEN, roč.~119, č.~4, s.~443-454. ISSN~0300-9564. doi:10.1007/s00702-011-0723-5. 2012.
|
