Detailed Information on Publication Record
2012
The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent
KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK and Irena REKTOROVÁBasic information
Original name
The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent
Authors
KRAJČOVIČOVÁ, Lenka (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Neural Transmission, Vídeň, SPRINGER WIEN, 2012, 0300-9564
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Austria
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.052
RIV identification code
RIV/00216224:14740/12:00064606
Organization unit
Central European Institute of Technology
UT WoS
000302423900005
Keywords in English
Parkinson's disease; Default mode network; Deactivation; Functional connectivity; Hippocampus; Levodopa
Tags
International impact, Reviewed
Změněno: 2/4/2013 09:05, Olga Křížová
Abstract
V originále
Disturbances in the default mode network (DMN) have been described in many neurological and psychiatric disorders including Parkinson's disease (PD). The DMN is characterized by basal activity that increases during rest or passive visual fixation and decreases ("deactivates'') during cognitive tasks. The network is believed to be involved in cognitive processes. We examined the DMN in PD patients on dopaminergic medication with normal cognitive performance compared to age-and gender-matched healthy controls (HC) using fMRI and three methodological procedures: independent component analysis of resting-state data, analysis of deactivation during a complex visual scene-encoding task, and seed-based functional connectivity analysis. In the PD group, we also studied the effect of dopaminergic medication on the DMN integrity. We did not find any difference between the PD and HC groups in the DMN, but using the daily levodopa equivalent dose as a covariate, we observed an enhanced functional connectivity of the DMN in the posterior cingulate cortex and decreased activation in the left parahippocampal gyrus during the cognitive task. We conclude that dopaminergic therapy has a specific effect on both the DMN integrity and task-related brain activations in cognitively unimpaired PD patients, and these effects seem to be dose-dependent.
Links
| ED1.1.00/02.0068, research and development project |
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