The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent

KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK and Irena REKTOROVÁ. The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent. Journal of Neural Transmission. Vídeň: SPRINGER WIEN, 2012, vol. 119, No 4, p. 443-454. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-011-0723-5.

Basic information

• Original name: The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent
• Authors: KRAJČOVIČOVÁ, Lenka (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Neural Transmission, Vídeň, SPRINGER WIEN, 2012, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.052
• RIV identification code: RIV/00216224:14740/12:00064606
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1007/s00702-011-0723-5
• UT WoS: 000302423900005
• Keywords in English: Parkinson's disease; Default mode network; Deactivation; Functional connectivity; Hippocampus; Levodopa
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Disturbances in the default mode network (DMN) have been described in many neurological and psychiatric disorders including Parkinson's disease (PD). The DMN is characterized by basal activity that increases during rest or passive visual fixation and decreases ("deactivates'') during cognitive tasks. The network is believed to be involved in cognitive processes. We examined the DMN in PD patients on dopaminergic medication with normal cognitive performance compared to age-and gender-matched healthy controls (HC) using fMRI and three methodological procedures: independent component analysis of resting-state data, analysis of deactivation during a complex visual scene-encoding task, and seed-based functional connectivity analysis. In the PD group, we also studied the effect of dopaminergic medication on the DMN integrity. We did not find any difference between the PD and HC groups in the DMN, but using the daily levodopa equivalent dose as a covariate, we observed an enhanced functional connectivity of the DMN in the posterior cingulate cortex and decreased activation in the left parahippocampal gyrus during the cognitive task. We conclude that dopaminergic therapy has a specific effect on both the DMN integrity and task-related brain activations in cognitively unimpaired PD patients, and these effects seem to be dose-dependent.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology