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@article{1094399,
author = {Vácha, Robert and MartinezandVeracoechea, Francisco J. and Frenkel, Daan},
article_location = {WASHINGTON},
article_number = {12},
doi = {http://dx.doi.org/10.1021/nn303508c},
keywords = {cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics},
language = {eng},
issn = {1936-0851},
journal = {ACS Nano},
title = {Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction},
url = {http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP},
volume = {6},
year = {2012}
}
TY - JOUR
ID - 1094399
AU - Vácha, Robert - Martinez-Veracoechea, Francisco J. - Frenkel, Daan
PY - 2012
TI - Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction
JF - ACS Nano
VL - 6
IS - 12
SP - 10598-10605
EP - 10598-10605
PB - American Chemical Society
SN - 19360851
KW - cytosol release
KW - late endosome
KW - ligand-receptor interaction
KW - phospholipid membrane
KW - nanoparticle shape
KW - molecular dynamics
UR - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
L2 - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
N2 - During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles.
ER -
VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA and Daan FRENKEL. Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction. \textit{ACS Nano}. WASHINGTON: American Chemical Society, 2012, vol.~6, No~12, p.~10598-10605. ISSN~1936-0851. Available from: https://dx.doi.org/10.1021/nn303508c.
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