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@article{1094399, author = {Vácha, Robert and MartinezandVeracoechea, Francisco J. and Frenkel, Daan}, article_location = {WASHINGTON}, article_number = {12}, doi = {http://dx.doi.org/10.1021/nn303508c}, keywords = {cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics}, language = {eng}, issn = {1936-0851}, journal = {ACS Nano}, title = {Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction}, url = {http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP}, volume = {6}, year = {2012} }
TY - JOUR ID - 1094399 AU - Vácha, Robert - Martinez-Veracoechea, Francisco J. - Frenkel, Daan PY - 2012 TI - Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction JF - ACS Nano VL - 6 IS - 12 SP - 10598-10605 EP - 10598-10605 PB - American Chemical Society SN - 19360851 KW - cytosol release KW - late endosome KW - ligand-receptor interaction KW - phospholipid membrane KW - nanoparticle shape KW - molecular dynamics UR - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP L2 - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP N2 - During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles. ER -
VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA and Daan FRENKEL. Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction. \textit{ACS Nano}. WASHINGTON: American Chemical Society, 2012, vol.~6, No~12, p.~10598-10605. ISSN~1936-0851. Available from: https://dx.doi.org/10.1021/nn303508c.
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