Intracellular Release of Endocytosed Nanoparticles Upon a
Change of Ligand-Receptor Interaction

J 2012

Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction

VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA and Daan FRENKEL

Basic information

Original name

Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction

Authors

VÁCHA, Robert (203 Czech Republic, guarantor, belonging to the institution), Francisco J. MARTINEZ-VERACOECHEA (826 United Kingdom of Great Britain and Northern Ireland) and Daan FRENKEL (826 United Kingdom of Great Britain and Northern Ireland)

Edition

ACS Nano, WASHINGTON, American Chemical Society, 2012, 1936-0851

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10403 Physical chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 12.062

RIV identification code

RIV/00216224:14740/12:00064625

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1021/nn303508c

UT WoS

000312563600020

Keywords in English

cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics

Abstract

V originále

During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

286154, interní kód MU

Name: SYLICA - Synergies of Life and Material Sciences to Create a New Future (Acronym: SYLICA)

Investor: European Union, Capacities

Citovat

VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA and Daan FRENKEL. Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction. ACS Nano. WASHINGTON: American Chemical Society, 2012, vol. 6, No 12, p. 10598-10605. ISSN 1936-0851. Available from: https://dx.doi.org/10.1021/nn303508c.

@article{1094399,
   author = {Vácha, Robert and MartinezandVeracoechea, Francisco J. and Frenkel, Daan},
   article_location = {WASHINGTON},
   article_number = {12},
   doi = {http://dx.doi.org/10.1021/nn303508c},
   keywords = {cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics},
   language = {eng},
   issn = {1936-0851},
   journal = {ACS Nano},
   title = {Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction},
   url = {http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP},
   volume = {6},
   year = {2012}
}

TY  - JOUR
ID  - 1094399
AU  - Vácha, Robert - Martinez-Veracoechea, Francisco J. - Frenkel, Daan
PY  - 2012
TI  - Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction
JF  - ACS Nano
VL  - 6
IS  - 12
SP  - 10598-10605
EP  - 10598-10605
PB  - American Chemical Society
SN  - 19360851
KW  - cytosol release
KW  - late endosome
KW  - ligand-receptor interaction
KW  - phospholipid membrane
KW  - nanoparticle shape
KW  - molecular dynamics
UR  - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
L2  - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
N2  - During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles.
ER  -

VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA and Daan FRENKEL. Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction. \textit{ACS Nano}. WASHINGTON: American Chemical Society, 2012, vol.~6, No~12, p.~10598-10605. ISSN~1936-0851. Available from: https://dx.doi.org/10.1021/nn303508c.

Detailed Information on Publication Record