Detailed Information on Publication Record
2013
Pluripotent stem cells and gene therapy
ŠIMARA, Pavel, Jason MOTL and Dan KAUFMANBasic information
Original name
Pluripotent stem cells and gene therapy
Authors
ŠIMARA, Pavel (203 Czech Republic, guarantor, belonging to the institution), Jason MOTL (840 United States of America) and Dan KAUFMAN (840 United States of America)
Edition
Translational Research, 2013, 1931-5244
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10601 Cell biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.044
RIV identification code
RIV/00216224:14330/13:00068030
Organization unit
Faculty of Informatics
UT WoS
000316837400008
Keywords in English
pluripotent stem cells; gene therapy
Tags
Změněno: 2/3/2018 10:11, Mgr. Pavel Šimara, Ph.D.
Abstract
V originále
Human pluripotent stem cells represent an accessible cell source for novel cell-based clinical research and therapies. With the realization of induced pluripotent stem cells (iPSCs), it is possible to produce almost any desired cell type from any patient's cells. Current developments in gene modification methods have opened the possibility for creating genetically corrected human iPSCs for certain genetic diseases that could be used later in autologous transplantation. Promising preclinical studies have demonstrated correction of disease-causing mutations in a number of hematological, neuronal, and muscular disorders. This review aims to summarize these recent advances with a focus on iPSC generation techniques, as well as gene modification methods. We will then further discuss some of the main obstacles remaining to be overcome before successful application of human pluripotent stem cell-based therapy arrives in the clinic and what the future of stem cell research may look like.
Links
| MSM0021622430, plan (intention) |
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