Driven hematopoietic differentiation of embryonic stem cells:
Epigenetic perspectives

J 2014

Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives

TESAŘOVÁ, Lenka, Stanislav STEJSKAL and Irena KRONTORÁD KOUTNÁ

Basic information

Original name

Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives

Authors

TESAŘOVÁ, Lenka (203 Czech Republic, belonging to the institution), Stanislav STEJSKAL (203 Czech Republic, belonging to the institution) and Irena KRONTORÁD KOUTNÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

CURRENT PHARMACEUTICAL DESIGN, SHARJAH, BENTHAM SCIENCE PUBL LTD, 2014, 1381-6128

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United Arab Emirates

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.452

RIV identification code

RIV/00216224:14330/14:00073400

Organization unit

Faculty of Informatics

DOI

http://dx.doi.org/10.2174/13816128113199990524

UT WoS

000334311500011

Keywords in English

epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development

Abstract

V originále

Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.

Links

GBP302/12/G157, research and development project

Name: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii

Investor: Czech Science Foundation

MSM0021622430, plan (intention)

Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

Citovat

TESAŘOVÁ, Lenka, Stanislav STEJSKAL and Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. CURRENT PHARMACEUTICAL DESIGN. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, vol. 20, No 11, p. 1674-1686. ISSN 1381-6128. Available from: https://dx.doi.org/10.2174/13816128113199990524.

@article{1095798,
   author = {Tesařová, Lenka and Stejskal, Stanislav and Krontorád Koutná, Irena},
   article_location = {SHARJAH},
   article_number = {11},
   doi = {http://dx.doi.org/10.2174/13816128113199990524},
   keywords = {epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development},
   language = {eng},
   issn = {1381-6128},
   journal = {CURRENT PHARMACEUTICAL DESIGN},
   title = {Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives},
   volume = {20},
   year = {2014}
}

TY  - JOUR
ID  - 1095798
AU  - Tesařová, Lenka - Stejskal, Stanislav - Krontorád Koutná, Irena
PY  - 2014
TI  - Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives
JF  - CURRENT PHARMACEUTICAL DESIGN
VL  - 20
IS  - 11
SP  - 1674-1686
EP  - 1674-1686
PB  - BENTHAM SCIENCE PUBL LTD
SN  - 13816128
KW  - epigenetic
KW  - stem cells
KW  - pluripotency
KW  - cell differentiation
KW  - hematopoietic development
N2  - Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.
ER  -

TESAŘOVÁ, Lenka, Stanislav STEJSKAL and Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. \textit{CURRENT PHARMACEUTICAL DESIGN}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, vol.~20, No~11, p.~1674-1686. ISSN~1381-6128. Available from: https://dx.doi.org/10.2174/13816128113199990524.

Detailed Information on Publication Record