Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives

TESAŘOVÁ, Lenka, Stanislav STEJSKAL and Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. CURRENT PHARMACEUTICAL DESIGN. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, vol. 20, No 11, p. 1674-1686. ISSN 1381-6128. Available from: https://dx.doi.org/10.2174/13816128113199990524.

Basic information

• Original name: Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives
• Authors: TESAŘOVÁ, Lenka (203 Czech Republic, belonging to the institution), Stanislav STEJSKAL (203 Czech Republic, belonging to the institution) and Irena KRONTORÁD KOUTNÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: CURRENT PHARMACEUTICAL DESIGN, SHARJAH, BENTHAM SCIENCE PUBL LTD, 2014, 1381-6128.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10601 Cell biology
• Country of publisher: United Arab Emirates
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.452
• RIV identification code: RIV/00216224:14330/14:00073400
• Organization unit: Faculty of Informatics
• Doi: http://dx.doi.org/10.2174/13816128113199990524
• UT WoS: 000334311500011
• Keywords in English: epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development
• Tags: cbia-web

Abstract

Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.

Links

• GBP302/12/G157, research and development project: Name: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii

Investor: Czech Science Foundation

• MSM0021622430, plan (intention): Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies