TESAŘOVÁ, Lenka, Stanislav STEJSKAL and Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. CURRENT PHARMACEUTICAL DESIGN. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, vol. 20, No 11, p. 1674-1686. ISSN 1381-6128. Available from: https://dx.doi.org/10.2174/13816128113199990524. |
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@article{1095798, author = {Tesařová, Lenka and Stejskal, Stanislav and Krontorád Koutná, Irena}, article_location = {SHARJAH}, article_number = {11}, doi = {http://dx.doi.org/10.2174/13816128113199990524}, keywords = {epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development}, language = {eng}, issn = {1381-6128}, journal = {CURRENT PHARMACEUTICAL DESIGN}, title = {Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives}, volume = {20}, year = {2014} }
TY - JOUR ID - 1095798 AU - Tesařová, Lenka - Stejskal, Stanislav - Krontorád Koutná, Irena PY - 2014 TI - Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives JF - CURRENT PHARMACEUTICAL DESIGN VL - 20 IS - 11 SP - 1674-1686 EP - 1674-1686 PB - BENTHAM SCIENCE PUBL LTD SN - 13816128 KW - epigenetic KW - stem cells KW - pluripotency KW - cell differentiation KW - hematopoietic development N2 - Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed. ER -
TESAŘOVÁ, Lenka, Stanislav STEJSKAL and Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. \textit{CURRENT PHARMACEUTICAL DESIGN}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, vol.~20, No~11, p.~1674-1686. ISSN~1381-6128. Available from: https://dx.doi.org/10.2174/13816128113199990524.
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