MicroRNAs involved in chemo- and radioresistance of high-grade
gliomas

J 2013

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ

Basic information

Original name

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Authors

BEŠŠE, Andrej (703 Slovakia, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Tumor Biology, Dordrecht, Springer, 2013, 1010-4283

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.840

RIV identification code

RIV/00216224:14740/13:00065588

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s13277-013-0772-5

UT WoS

000321912500001

Keywords in English

microRNA; chemoresistance; radioresistance; high-grade gliomas

Abstract

V originále

High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13514, research and development project

Name: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem

Citovat

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. Tumor Biology. Dordrecht: Springer, 2013, vol. 34, No 4, p. 1969-1978. ISSN 1010-4283. Available from: https://dx.doi.org/10.1007/s13277-013-0772-5.

@article{1103756,
   author = {Bešše, Andrej and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej},
   article_location = {Dordrecht},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s13277-013-0772-5},
   keywords = {microRNA; chemoresistance; radioresistance; high-grade gliomas},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {MicroRNAs involved in chemo- and radioresistance of high-grade gliomas},
   volume = {34},
   year = {2013}
}

TY  - JOUR
ID  - 1103756
AU  - Bešše, Andrej - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej
PY  - 2013
TI  - MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
JF  - Tumor Biology
VL  - 34
IS  - 4
SP  - 1969-1978
EP  - 1969-1978
PB  - Springer
SN  - 10104283
KW  - microRNA
KW  - chemoresistance
KW  - radioresistance
KW  - high-grade gliomas
N2  - High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.
ER  -

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. \textit{Tumor Biology}. Dordrecht: Springer, 2013, vol.~34, No~4, p.~1969-1978. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-013-0772-5.

Detailed Information on Publication Record