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@article{1103756, author = {Bešše, Andrej and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej}, article_location = {Dordrecht}, article_number = {4}, doi = {http://dx.doi.org/10.1007/s13277-013-0772-5}, keywords = {microRNA; chemoresistance; radioresistance; high-grade gliomas}, language = {eng}, issn = {1010-4283}, journal = {Tumor Biology}, title = {MicroRNAs involved in chemo- and radioresistance of high-grade gliomas}, volume = {34}, year = {2013} }
TY - JOUR ID - 1103756 AU - Bešše, Andrej - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej PY - 2013 TI - MicroRNAs involved in chemo- and radioresistance of high-grade gliomas JF - Tumor Biology VL - 34 IS - 4 SP - 1969-1978 EP - 1969-1978 PB - Springer SN - 10104283 KW - microRNA KW - chemoresistance KW - radioresistance KW - high-grade gliomas N2 - High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy. ER -
BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. \textit{Tumor Biology}. Dordrecht: Springer, 2013, vol.~34, No~4, p.~1969-1978. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-013-0772-5.
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