KLUMPLEROVÁ, Marie, Leona VYCHODILOVA, Olga BOBROVA, Michaela CVANOVÁ, Ján FUTAS, Eva JANOVA, Mirko VYSKOCIL, Irena VRTKOVA, Lenka PUTNOVÁ, Ladislav DUŠEK, Eliane MARTI a Petr HORIN. Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses. MOLECULAR BIOLOGY REPORTS. DORDRECHT: SPRINGER, 2013, Vol. 40, č. 4, s. 3333-3340. ISSN 0301-4851. doi:10.1007/s11033-012-2408-z.
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Základní údaje
Originální název Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses
Autoři KLUMPLEROVÁ, Marie (203 Česká republika), Leona VYCHODILOVA (203 Česká republika), Olga BOBROVA (203 Česká republika), Michaela CVANOVÁ (203 Česká republika, domácí), Ján FUTAS (703 Slovensko), Eva JANOVA (203 Česká republika), Mirko VYSKOCIL (203 Česká republika), Irena VRTKOVA (203 Česká republika), Lenka PUTNOVÁ (203 Česká republika), Ladislav DUŠEK (203 Česká republika, garant, domácí), Eliane MARTI (756 Švýcarsko) a Petr HORIN (203 Česká republika).
Vydání MOLECULAR BIOLOGY REPORTS, DORDRECHT, SPRINGER, 2013, 0301-4851.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Genetika a molekulární biologie
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.958
Kód RIV RIV/00216224:14110/13:00068267
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1007/s11033-012-2408-z
UT WoS 000316221100062
Klíčová slova anglicky Horse; Insect bite hypersensitivity; Major histocompatibility complex; Association analysis
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 8. 8. 2013 16:41.
Anotace
Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of insects. IBH is a multifactorial disease with contribution of genetic and environmental factors. Candidate gene association analysis of IBH was performed in a group of 89 Icelandic horses all born in Iceland and imported to Europe. Horses were classified in IBH-affected and non-affected based on clinical signs and history of recurrent dermatitis, and on the results of an in vitro sulfidoleukotriene (sLT)-release assay with Culicoides nubeculosus and Simulium vittatum extract. Different genetic markers were tested for association with IBH by the Fisher's exact test. The effect of the major histocompatibility complex (MHC) gene region was studied by genotyping five microsatellites spanning the MHC region (COR112, COR113, COR114, UM011 and UMN-JH34-2), and exon 2 polymorphisms of the class II Eqca-DRA gene. Associations with Eqca-DRA and COR113 were identified (p < 0.05). In addition, a panel of 20 single nucleotide polymorphisms (SNPs) in 17 candidate allergy-related genes was tested. During the initial screen, no marker from the panel was significantly (p < 0.05) associated with IBH. Five SNPs associated with IBH at p < 0.10 were therefore used for analysis of combined genotypes. Out of them, SNPs located in the genes coding for the CD14 receptor (CD14), interleukin 23 receptor (IL23R), thymic stromal lymphopoietin (TSLP) and transforming growth factor beta 3 (TGFB3) molecules were associated with IBH as parts of complex genotypes. These results are supported by similar associations and by expression data from different horse populations and from human studies.
VytisknoutZobrazeno: 16. 5. 2022 08:27