| WONG, G. K., S. GOLDACKER, C. WINTERHALTER, B. GRIMBACHER, H. CHAPEL, M. LUCAS, D. ALECSANDRU, D. MCEWEN, I. QUINTI, H. MARTINI, R. E. SCHMIDT, D. ERNST, T. ESPANOL, A. VIDALLER, J. CARBONE, E. FERNANDEZ-CRUZ, V. LOUGARIS, A. PLEBANI, N. KUTUKCULER, L. I. GONZALEZ-GRANADO, R. CONTRERAS, S. KIANI-ALIKHAN, M. A. A. IBRAHIM, Jiří LITZMAN, A. JONES, H. B. GASPAR, L. HAMMARSTROM, U. BAUMANN, K. WARNATZ and A. P. HUISSOON. Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients. Clinical and Experimental Immunology. Hoboken: Blackwell Publishing, 2013, vol. 172, No 1, p. 63-72. ISSN 0009-9104. doi:10.1111/cei.12039. |
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@article{1106751,
author = {Wong, G. K. and Goldacker, S. and Winterhalter, C. and Grimbacher, B. and Chapel, H. and Lucas, M. and Alecsandru, D. and McEwen, D. and Quinti, I. and Martini, H. and Schmidt, R. E. and Ernst, D. and Espanol, T. and Vidaller, A. and Carbone, J. and FernandezandCruz, E. and Lougaris, V. and Plebani, A. and Kutukculer, N. and GonzalezandGranado, L. I. and Contreras, R. and KianiandAlikhan, S. and Ibrahim, M. A. A. and Litzman, Jiří and Jones, A. and Gaspar, H. B. and Hammarstrom, L. and Baumann, U. and Warnatz, K. and Huissoon, A. P.},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1111/cei.12039},
keywords = {autoimmune cytopenia; common variable immunodeficiency; splenectomy; splenomegaly},
language = {eng},
issn = {0009-9104},
journal = {Clinical and Experimental Immunology},
title = {Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients},
volume = {172},
year = {2013}
}
TY - JOUR
ID - 1106751
AU - Wong, G. K. - Goldacker, S. - Winterhalter, C. - Grimbacher, B. - Chapel, H. - Lucas, M. - Alecsandru, D. - McEwen, D. - Quinti, I. - Martini, H. - Schmidt, R. E. - Ernst, D. - Espanol, T. - Vidaller, A. - Carbone, J. - Fernandez-Cruz, E. - Lougaris, V. - Plebani, A. - Kutukculer, N. - Gonzalez-Granado, L. I. - Contreras, R. - Kiani-Alikhan, S. - Ibrahim, M. A. A. - Litzman, Jiří - Jones, A. - Gaspar, H. B. - Hammarstrom, L. - Baumann, U. - Warnatz, K. - Huissoon, A. P.
PY - 2013
TI - Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients
JF - Clinical and Experimental Immunology
VL - 172
IS - 1
SP - 63-72
EP - 63-72
PB - Blackwell Publishing
SN - 00099104
KW - autoimmune cytopenia
KW - common variable immunodeficiency
KW - splenectomy
KW - splenomegaly
N2 - Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about the potential of compounding an existing immunodeficiency. With increasing use of rituximab as an alternative treatment for refractory autoimmune cytopenia, the role of splenectomy in CVID needs to be re-examined. This retrospective study provides the largest cohesive data set to date describing the outcome of splenectomy in 45 CVID patients in the past 40 years. Splenectomy proved to be an effective long-term treatment in 75% of CVID patients with autoimmune cytopenia, even in some cases when rituximab had failed. Splenectomy does not worsen mortality in CVID and adequate immunoglobulin replacement therapy appears to play a protective role in overwhelming post-splenectomy infections. Future trials comparing the effectiveness and safety of rituximab and splenectomy are needed to provide clearer guidance on the second-line management of autoimmune cytopenia in CVID.
ER -
WONG, G. K., S. GOLDACKER, C. WINTERHALTER, B. GRIMBACHER, H. CHAPEL, M. LUCAS, D. ALECSANDRU, D. MCEWEN, I. QUINTI, H. MARTINI, R. E. SCHMIDT, D. ERNST, T. ESPANOL, A. VIDALLER, J. CARBONE, E. FERNANDEZ-CRUZ, V. LOUGARIS, A. PLEBANI, N. KUTUKCULER, L. I. GONZALEZ-GRANADO, R. CONTRERAS, S. KIANI-ALIKHAN, M. A. A. IBRAHIM, Jiří LITZMAN, A. JONES, H. B. GASPAR, L. HAMMARSTROM, U. BAUMANN, K. WARNATZ and A. P. HUISSOON. Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients. \textit{Clinical and Experimental Immunology}. Hoboken: Blackwell Publishing, 2013, vol.~172, No~1, p.~63-72. ISSN~0009-9104. doi:10.1111/cei.12039.
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