MEBAZAA, Alexandre, Jindřich ŠPINAR, Etienne GAYAT, Johan LASSUS, Taly MEAS, Christian MUELLER, Aldo MAGGIONI, Frank PEACOCK, Harjola VELI-PEKKA, Roland van KIMMENADE, Atul PATHAK, Thomas MUELLER, Luigi TAVAZZI, Salvatore di SOMMA, Marco METRA, Domingo PASCUAL-FIGAL, Said LARIBI, Damien LOGEART, Semir NOUIRA, Naoki SATO, Jiří PAŘENICA, Nicolas DEYE, Riadh BOUKEF, Corinne COLLET, Greet Van den BERGHE, Alain COHEN-SOLAL a James L. Jr. JANUZZI. Association Between Elevated Blood Glucose and Outcome in Acute Heart Failure Results From an International Observational Cohort. Journal of The American College of Cardiology. New York: Elsevier Science Inc., 2013, roč. 61, č. 8, s. 820-829. ISSN 0735-1097. doi:10.1016/j.jacc.2012.11.054.
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Základní údaje
Originální název Association Between Elevated Blood Glucose and Outcome in Acute Heart Failure Results From an International Observational Cohort
Autoři MEBAZAA, Alexandre (250 Francie), Jindřich ŠPINAR (203 Česká republika, garant, domácí), Etienne GAYAT (250 Francie), Johan LASSUS (246 Finsko), Taly MEAS (250 Francie), Christian MUELLER (756 Švýcarsko), Aldo MAGGIONI (380 Itálie), Frank PEACOCK (840 Spojené státy), Harjola VELI-PEKKA (246 Finsko), Roland van KIMMENADE (528 Nizozemsko), Atul PATHAK (250 Francie), Thomas MUELLER (40 Rakousko), Luigi TAVAZZI (380 Itálie), Salvatore di SOMMA (380 Itálie), Marco METRA (380 Itálie), Domingo PASCUAL-FIGAL (724 Španělsko), Said LARIBI (250 Francie), Damien LOGEART (250 Francie), Semir NOUIRA (788 Tunisko), Naoki SATO (392 Japonsko), Jiří PAŘENICA (203 Česká republika, domácí), Nicolas DEYE (250 Francie), Riadh BOUKEF (250 Francie), Corinne COLLET (250 Francie), Greet Van den BERGHE (56 Belgie), Alain COHEN-SOLAL (250 Francie) a James L. Jr. JANUZZI (840 Spojené státy).
Vydání Journal of The American College of Cardiology, New York, Elsevier Science Inc. 2013, 0735-1097.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30201 Cardiac and Cardiovascular systems
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 15.343
Kód RIV RIV/00216224:14110/13:00068284
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.jacc.2012.11.054
UT WoS 000315199400005
Klíčová slova anglicky acute heart failure; blood glucose; 30-day mortality; hyperglycemia
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 11. 10. 2013 14:41.
Anotace
Objective The aim of this analysis was to assess the association between elevated blood glucose level and mortality in acute heart failure (AHF). Background Elevated blood glucose has been reported to be prognostically meaningful in patients with cardiac diagnoses, such as coronary artery disease. The short-term prognostic impact of hyperglycemia in AHF is unknown, however. Methods In a multinational cohort of AHF, we examined the ability of blood glucose concentrations at presentation to predict all-cause mortality by 30 days. Fully adjusted models for prognosis included a previous diagnosis of diabetes mellitus as a covariate. Results A total of 6,212 subjects with AHF (mean age, 72 years; 52.5% male) were studied; the median blood glucose concentration on arrival at the hospital was 7.5 mmol/l (135 mg/dl), and 41% had a previous diagnosis of diabetes mellitus (DM). After 30 days, 618 patients (10%) had died. Compared with survivors, decedents had significantly higher median blood glucose concentrations (8.9 mmol/l vs. 7.4 mmol/l; p < 0.0001). In the fully adjusted model, an elevated blood glucose level was an independent predictor of 30-day mortality in AHF (odds ratio: 2.19; 95% confidence interval: 1.69 to 2.83; p < 0.001). The risk associated with an elevated blood glucose level appeared consistent across all subgroups of patients, including patients with preserved (hazard ratio: 5.41; 95% confidence interval: 2.44 to 12.0; p < 0.0001) and impaired systolic function (hazard ratio: 2.37; 95% confidence interval: 1.57 to 3.59; p < 0.0001). Furthermore, in reclassification analyses, elevated blood glucose added significant prognostic information to clinical parameters alone (4.4% net reclassification improvement; p = 0.01). Conclusions Among patients with AHF, blood glucose concentrations at presentation are powerfully prognostic for 30-day mortality, independent of a diagnosis of diabetes mellitus or other clinical variables. Because blood glucose is easily modifiable, it may represent a valid target for therapeutic intervention. (J Am Coll Cardiol 2013;61:820-9) (C) 2013 by the American College of Cardiology Foundation
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