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ATTARBASCHI, Andishe, Auke BEISHUIZEN, Georg MANN, Angelo ROSOLEN, Tetsuya MORI, Anne UYTTEBROECK, Felix NIGGLI, Monika CSOKA, Zdenka KŘENOVÁ, Karin MELLGREN, Edita KABICKOVA, Alan KS CHIANG, Alfred REITER, Denise WILLIAMS and Birgit BURKHARDT. Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection. Annals of hematology. Berlin: Springer Verlag, 2013, vol. 92, No 11, p. 1537-1541. ISSN 0939-5555. Available from: https://dx.doi.org/10.1007/s00277-013-1785-2.

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Basic information
Original name	Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection
Authors	ATTARBASCHI, Andishe (40 Austria), Auke BEISHUIZEN (528 Netherlands), Georg MANN (40 Austria), Angelo ROSOLEN (380 Italy), Tetsuya MORI (392 Japan), Anne UYTTEBROECK (56 Belgium), Felix NIGGLI (756 Switzerland), Monika CSOKA (348 Hungary), Zdenka KŘENOVÁ (203 Czech Republic, guarantor, belonging to the institution), Karin MELLGREN (752 Sweden), Edita KABICKOVA (203 Czech Republic), Alan KS CHIANG (344 Hong Kong), Alfred REITER (276 Germany), Denise WILLIAMS (826 United Kingdom of Great Britain and Northern Ireland) and Birgit BURKHARDT (276 Germany).
Edition	Annals of hematology, Berlin, Springer Verlag, 2013, 0939-5555.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30200 3.2 Clinical medicine
Country of publisher	Germany
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 2.396
RIV identification code	RIV/00216224:14110/13:00068306
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.1007/s00277-013-1785-2
UT WoS	000325357600012
Keywords in English	"Watch and wait"; Complete resection; Follicular lymphoma; Outcome
Tags	International impact, Reviewed
Changed by	Changed by: Soňa Böhmová, učo 232884. Changed: 18/12/2013 15:34.

Abstract
Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % >/- 10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 +/- 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.

Abstract

Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % >/- 10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 +/- 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.