Mucoadhesive films as perspective oral dosage form

J 2013

Mucoadhesive films as perspective oral dosage form

LANDOVÁ, Hana, Jan GADZIONOK, David VETCHÝ, Jan ŠTEMBÍREK, Zdeněk DANĚK et. al.

Basic information

Original name

Mucoadhesive films as perspective oral dosage form

Authors

LANDOVÁ, Hana (203 Czech Republic, guarantor), Jan GADZIONOK (203 Czech Republic), David VETCHÝ (203 Czech Republic), Jan ŠTEMBÍREK (203 Czech Republic) and Zdeněk DANĚK (203 Czech Republic, belonging to the institution)

Edition

Česká a slovenská farmacie, Praha, Česká lékařská společnost J. E. Purkyně, 2013, 1210-7816

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/13:00068323

Organization unit

Faculty of Medicine

Keywords in English

oral mucosa; mucoadhesion principles; mucoadhesive dosage forms; films; patches; discs

Změněno: 17/5/2013 17:09, Soňa Böhmová

Abstract

V originále

Mucoadhesion is a specific phenomenon of creating bonds during intimate contact between biological surfaces covered by a mucus layer and a mucoadhesive material. In recent years come to the forefront of interest in the pharmaceutical industry modern dosage forms based on this specific process. Films (discs, patches) composed of mucoadhesive polymers (cellulose derivatives, polyacrylates, polyoxyethylene, etc.) prepared by established methods (solvent casting, hot melt extrusion, etc.) could be perspective candidates for oral administration of many drugs due to their flexibility and comfortable use. In addition, they can circumvent the relatively short residence time of conventional oral dosage forms on the mucosa and provide a precisely measured drug dose to the application site. Moreover, they can also help to protect the wound surface, thus help to reduce pain and improve effectiveness of the therapy. The aim of this article is to give an overview about the principles of creation of mucoadhesive bonds and about novel dosage form – mucoadhesive films in terms of their composition, preparation and practical usage.

Citovat

LANDOVÁ, Hana, Jan GADZIONOK, David VETCHÝ, Jan ŠTEMBÍREK and Zdeněk DANĚK. Mucoadhesive films as perspective oral dosage form (Mukoadhezivní filmy jako perspektivní lékové formy pro orální podání). Česká a slovenská farmacie. Praha: Česká lékařská společnost J. E. Purkyně, 2013, roč. 62, č. 1, p. 4-11. ISSN 1210-7816.

@article{1107020,
   author = {Landová, Hana and Gadzionok, Jan and Vetchý, David and Štembírek, Jan and Daněk, Zdeněk},
   article_location = {Praha},
   article_number = {č. 1},
   keywords = {oral mucosa; mucoadhesion principles; mucoadhesive dosage forms; films; patches; discs},
   language = {eng},
   issn = {1210-7816},
   journal = {Česká a slovenská farmacie},
   title = {Mucoadhesive films as perspective oral dosage form},
   volume = {roč. 62},
   year = {2013}
}

TY  - JOUR
ID  - 1107020
AU  - Landová, Hana - Gadzionok, Jan - Vetchý, David - Štembírek, Jan - Daněk, Zdeněk
PY  - 2013
TI  - Mucoadhesive films as perspective oral dosage form
JF  - Česká a slovenská farmacie
VL  - roč. 62
IS  - č. 1
SP  - 4-11
EP  - 4-11
PB  - Česká lékařská společnost J. E. Purkyně
SN  - 12107816
KW  - oral mucosa
KW  - mucoadhesion principles
KW  - mucoadhesive dosage forms
KW  - films
KW  - patches
KW  - discs
N2  - Mucoadhesion is a specific phenomenon of creating bonds during intimate contact between biological surfaces covered by a mucus layer and a mucoadhesive material. In recent years come to the forefront of interest in the pharmaceutical industry modern dosage forms based on this specific process. Films (discs, patches) composed of mucoadhesive polymers (cellulose derivatives, polyacrylates, polyoxyethylene, etc.) prepared by established methods (solvent casting, hot melt extrusion, etc.) could be perspective candidates for oral administration of many drugs due to their flexibility and comfortable use. In addition, they can circumvent the relatively short residence time of conventional oral dosage forms on the mucosa and provide a precisely measured drug dose to the application site. Moreover, they can also help to protect the wound surface, thus help to reduce pain and improve effectiveness of the therapy. The aim of this article is to give an overview about the principles of creation of mucoadhesive bonds and about novel dosage form – mucoadhesive films in terms of their composition, preparation and practical usage.
ER  -

LANDOVÁ, Hana, Jan GADZIONOK, David VETCHÝ, Jan ŠTEMBÍREK and Zdeněk DANĚK. Mucoadhesive films as perspective oral dosage form (Mukoadhezivní filmy jako perspektivní lékové formy pro orální podání). \textit{Česká a slovenská farmacie}. Praha: Česká lékařská společnost J. E. Purkyně, 2013, roč. 62, č. 1, p.~4-11. ISSN~1210-7816.

Detailed Information on Publication Record