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@article{1107771,
author = {Přikryl, Radovan and Přikrylová Kučerová, Hana},
article_location = {USA},
article_number = {1},
doi = {http://dx.doi.org/10.1097/YCT.0b013e318270295f},
keywords = {negative symptoms; schizophrenia; treatment; repetitive; transcranial magnetic stimulation; review},
language = {eng},
issn = {1095-0680},
journal = {Journal of ECT},
title = {Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia?},
volume = {29},
year = {2013}
}
TY - JOUR
ID - 1107771
AU - Přikryl, Radovan - Přikrylová Kučerová, Hana
PY - 2013
TI - Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia?
JF - Journal of ECT
VL - 29
IS - 1
SP - 67-74
EP - 67-74
PB - Lippincott Williams and Wilkins
SN - 10950680
KW - negative symptoms
KW - schizophrenia
KW - treatment
KW - repetitive
KW - transcranial magnetic stimulation
KW - review
N2 - Objective: Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making. Method: Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011. Results: Five open studies, 13 sham-controlled studies, and 2 metaanalysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43Y0.68). Conclusion: Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies. Clinical Recommendations: There is an evidence showing that rTMS can be considered the effective treatment option for negative symptoms of schizophrenia. Based on the results of current meta-analyses, the effect size of high-frequency rTMS in the treatment of negative symptoms of schizophrenia seems to be mild to moderate (Cohen d = 0.43Y0.63). Despite limited evidence base, the associations between efficacy and stimulation approaches (higher stimulation intensity, higher number of sessions or 10 Hz stimulus frequency) appear. Additional Comments: Neither the European Medicines Agency nor the Food and Drug Administration has approved rTMS for the treatment of negative symptoms of schizophrenia. Furthermore, large clinical studies are necessary to verify the natural benefit of rTMS for general clinical practice.
ER -
PŘIKRYL, Radovan a Hana PŘIKRYLOVÁ KUČEROVÁ. Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia? \textit{Journal of ECT}. USA: Lippincott Williams and Wilkins, roč.~29, č.~1, s.~67-74. ISSN~1095-0680. doi:10.1097/YCT.0b013e318270295f. 2013.
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