| RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. Research in Veterinary Sciences. Amsterdam: Elsevier, 2013, Vol. 95, No 1, p. 137-142. ISSN 0034-5288. doi:10.1016/j.rvsc.2013.03.011. |
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@article{1107885,
author = {Rusek, J. and Klumplerová, Marie and Molinková, Dobromila and Sedlinská, Markéta and Dušek, Ladislav and Mužík, Jan and Putnová, Lenka and Vrtková, Irena and Celer, Vladimír and Hořín, Petr},
article_location = {Amsterdam},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.rvsc.2013.03.011},
keywords = {Antibody responsiveness; Equine herpes virus; Immunity-related molecular markers; Microsatellites; Statistical associations},
language = {eng},
issn = {0034-5288},
journal = {Research in Veterinary Sciences},
title = {Genetics of anti-EHV antibody responses in a horse population},
volume = {Vol. 95},
year = {2013}
}
TY - JOUR
ID - 1107885
AU - Rusek, J. - Klumplerová, Marie - Molinková, Dobromila - Sedlinská, Markéta - Dušek, Ladislav - Mužík, Jan - Putnová, Lenka - Vrtková, Irena - Celer, Vladimír - Hořín, Petr
PY - 2013
TI - Genetics of anti-EHV antibody responses in a horse population
JF - Research in Veterinary Sciences
VL - Vol. 95
IS - 1
SP - 137-142
EP - 137-142
PB - Elsevier
SN - 00345288
KW - Antibody responsiveness
KW - Equine herpes virus
KW - Immunity-related molecular markers
KW - Microsatellites
KW - Statistical associations
N2 - Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections.
ER -
RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. \textit{Research in Veterinary Sciences}. Amsterdam: Elsevier, 2013, Vol. 95, No~1, p.~137-142. ISSN~0034-5288. doi:10.1016/j.rvsc.2013.03.011.
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