RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. Research in Veterinary Sciences. Amsterdam: Elsevier, 2013, Vol. 95, No 1, p. 137-142. ISSN 0034-5288. doi:10.1016/j.rvsc.2013.03.011.
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Basic information
Original name Genetics of anti-EHV antibody responses in a horse population
Authors RUSEK, J. (203 Czech Republic, guarantor), Marie KLUMPLEROVÁ (203 Czech Republic), Dobromila MOLINKOVÁ (203 Czech Republic), Markéta SEDLINSKÁ (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Jan MUŽÍK (203 Czech Republic, belonging to the institution), Lenka PUTNOVÁ (203 Czech Republic), Irena VRTKOVÁ (203 Czech Republic), Vladimír CELER (203 Czech Republic) and Petr HOŘÍN (203 Czech Republic).
Edition Research in Veterinary Sciences, Amsterdam, Elsevier, 2013, 0034-5288.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.511
RIV identification code RIV/00216224:14110/13:00068374
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.rvsc.2013.03.011
UT WoS 000320289600022
Keywords in English Antibody responsiveness; Equine herpes virus; Immunity-related molecular markers; Microsatellites; Statistical associations
Tags Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 8. 8. 2013 16:35.
Abstract
Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections.
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