Trefoil factor 2 expression and its significance as a predictor
of severity of sepsis in children

J 2013

Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children

ŽUREK, Jiří, Michal KÝR, Martin VAVŘINA and Michal FEDORA

Basic information

Original name

Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children

Authors

ŽUREK, Jiří (203 Czech Republic, guarantor, belonging to the institution), Michal KÝR (203 Czech Republic, belonging to the institution), Martin VAVŘINA (203 Czech Republic, belonging to the institution) and Michal FEDORA (203 Czech Republic, belonging to the institution)

Edition

Peptides, NEW YORK, Elsevier, 2013, 0196-9781

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.614

RIV identification code

RIV/00216224:14110/13:00068502

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.peptides.2013.04.011

UT WoS

000322628600001

Keywords in English

Trefoil factor; Gut; Sepsis; Children; Mortalitya

Abstract

V originále

Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission. The second objective was to determine optimal cut-off value and quantify diagnostic characteristics of TFF2 between controls and patients with various septic states. The study included 57 children aged 0-19 years, with expected or proven SIRS and septic condition. The degree of severity was evaluated according to PELOD Score (Pediatric Logistic Organ Dysfunction). Blood samples to determine levels of TFF2 factor were taken during the time patient met the criteria of SIRS or sepsis. Control group samples to determine the serum levels of TFF2 were taken from patients undergoing elective surgery. Analysis of TFF2 levels dynamics revealed that TFF2 levels kept steady state during the 5-day period. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome (MODS). The difference was noticed also in ROC analysis.

Citovat

ŽUREK, Jiří, Michal KÝR, Martin VAVŘINA and Michal FEDORA. Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children. Peptides. NEW YORK: Elsevier, 2013, vol. 46, August, p. 1-5. ISSN 0196-9781. Available from: https://dx.doi.org/10.1016/j.peptides.2013.04.011.

@article{1110239,
   author = {Žurek, Jiří and Kýr, Michal and Vavřina, Martin and Fedora, Michal},
   article_location = {NEW YORK},
   article_number = {August},
   doi = {http://dx.doi.org/10.1016/j.peptides.2013.04.011},
   keywords = {Trefoil factor; Gut; Sepsis; Children; Mortalitya},
   language = {eng},
   issn = {0196-9781},
   journal = {Peptides},
   title = {Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children},
   volume = {46},
   year = {2013}
}

TY  - JOUR
ID  - 1110239
AU  - Žurek, Jiří - Kýr, Michal - Vavřina, Martin - Fedora, Michal
PY  - 2013
TI  - Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children
JF  - Peptides
VL  - 46
IS  - August
SP  - 1-5
EP  - 1-5
PB  - Elsevier
SN  - 01969781
KW  - Trefoil factor
KW  - Gut
KW  - Sepsis
KW  - Children
KW  - Mortalitya
N2  - Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission. The second objective was to determine optimal cut-off value and quantify diagnostic characteristics of TFF2 between controls and patients with various septic states. The study included 57 children aged 0-19 years, with expected or proven SIRS and septic condition. The degree of severity was evaluated according to PELOD Score (Pediatric Logistic Organ Dysfunction). Blood samples to determine levels of TFF2 factor were taken during the time patient met the criteria of SIRS or sepsis. Control group samples to determine the serum levels of TFF2 were taken from patients undergoing elective surgery. Analysis of TFF2 levels dynamics revealed that TFF2 levels kept steady state during the 5-day period. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome (MODS). The difference was noticed also in ROC analysis.
ER  -

ŽUREK, Jiří, Michal KÝR, Martin VAVŘINA and Michal FEDORA. Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children. \textit{Peptides}. NEW YORK: Elsevier, 2013, vol.~46, August, p.~1-5. ISSN~0196-9781. Available from: https://dx.doi.org/10.1016/j.peptides.2013.04.011.

Detailed Information on Publication Record