ŽUREK, Jiří, Michal KÝR, Martin VAVŘINA and Michal FEDORA. Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children. Peptides. NEW YORK: Elsevier, 2013, vol. 46, August, p. 1-5. ISSN 0196-9781. Available from: https://dx.doi.org/10.1016/j.peptides.2013.04.011.
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Basic information
Original name Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children
Authors ŽUREK, Jiří (203 Czech Republic, guarantor, belonging to the institution), Michal KÝR (203 Czech Republic, belonging to the institution), Martin VAVŘINA (203 Czech Republic, belonging to the institution) and Michal FEDORA (203 Czech Republic, belonging to the institution).
Edition Peptides, NEW YORK, Elsevier, 2013, 0196-9781.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.614
RIV identification code RIV/00216224:14110/13:00068502
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.peptides.2013.04.011
UT WoS 000322628600001
Keywords in English Trefoil factor; Gut; Sepsis; Children; Mortalitya
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 31/1/2014 10:11.
Abstract
Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission. The second objective was to determine optimal cut-off value and quantify diagnostic characteristics of TFF2 between controls and patients with various septic states. The study included 57 children aged 0-19 years, with expected or proven SIRS and septic condition. The degree of severity was evaluated according to PELOD Score (Pediatric Logistic Organ Dysfunction). Blood samples to determine levels of TFF2 factor were taken during the time patient met the criteria of SIRS or sepsis. Control group samples to determine the serum levels of TFF2 were taken from patients undergoing elective surgery. Analysis of TFF2 levels dynamics revealed that TFF2 levels kept steady state during the 5-day period. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome (MODS). The difference was noticed also in ROC analysis.
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