| GESCHEIDT, Tomáš, Radek MAREČEK, Michal MIKL, Kristína CZEKÓOVÁ, Tomáš URBÁNEK, Jiří VANÍČEK, Daniel Joel SHAW and Martin BAREŠ. Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study. NEUROLOGICAL SCIENCES. Springer, 2013, vol. 34, No 12, p. 2159-2166. ISSN 1590-1874. Available from: https://dx.doi.org/10.1007/s10072-013-1439-0. |
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@article{1110342,
author = {Gescheidt, Tomáš and Mareček, Radek and Mikl, Michal and Czekóová, Kristína and Urbánek, Tomáš and Vaníček, Jiří and Shaw, Daniel Joel and Bareš, Martin},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s10072-013-1439-0},
keywords = {Parkinsos's disease; Iowa Gambling Task; Decision-making; Dopamine; fMRI; Psychophysiological interactions},
language = {eng},
issn = {1590-1874},
journal = {NEUROLOGICAL SCIENCES},
title = {Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study},
url = {http://link.springer.com/content/pdf/10.1007%2Fs10072-013-1439-0.pdf},
volume = {34},
year = {2013}
}
TY - JOUR
ID - 1110342
AU - Gescheidt, Tomáš - Mareček, Radek - Mikl, Michal - Czekóová, Kristína - Urbánek, Tomáš - Vaníček, Jiří - Shaw, Daniel Joel - Bareš, Martin
PY - 2013
TI - Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study
JF - NEUROLOGICAL SCIENCES
VL - 34
IS - 12
SP - 2159-2166
EP - 2159-2166
PB - Springer
SN - 15901874
KW - Parkinsos's disease
KW - Iowa Gambling Task
KW - Decision-making
KW - Dopamine
KW - fMRI
KW - Psychophysiological interactions
UR - http://link.springer.com/content/pdf/10.1007%2Fs10072-013-1439-0.pdf
L2 - http://link.springer.com/content/pdf/10.1007%2Fs10072-013-1439-0.pdf
N2 - The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson's disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on outcome evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.
ER -
GESCHEIDT, Tomáš, Radek MAREČEK, Michal MIKL, Kristína CZEKÓOVÁ, Tomáš URBÁNEK, Jiří VANÍČEK, Daniel Joel SHAW and Martin BAREŠ. Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study. \textit{NEUROLOGICAL SCIENCES}. Springer, 2013, vol.~34, No~12, p.~2159-2166. ISSN~1590-1874. Available from: https://dx.doi.org/10.1007/s10072-013-1439-0.
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