Detailed Information on Publication Record
2013
Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study
GESCHEIDT, Tomáš, Radek MAREČEK, Michal MIKL, Kristína CZEKÓOVÁ, Tomáš URBÁNEK et. al.Basic information
Original name
Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study
Authors
GESCHEIDT, Tomáš (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Kristína CZEKÓOVÁ (703 Slovakia, belonging to the institution), Tomáš URBÁNEK (203 Czech Republic), Jiří VANÍČEK (203 Czech Republic, belonging to the institution), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)
Edition
NEUROLOGICAL SCIENCES, Springer, 2013, 1590-1874
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.495
RIV identification code
RIV/00216224:14740/13:00068514
Organization unit
Central European Institute of Technology
UT WoS
000328209500011
Keywords in English
Parkinsos's disease; Iowa Gambling Task; Decision-making; Dopamine; fMRI; Psychophysiological interactions
Tags
International impact, Reviewed
Změněno: 15/3/2018 10:14, Mgr. et Mgr. Kristína Czekóová, Ph.D.
Abstract
V originále
The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson's disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on outcome evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.
Links
| ED1.1.00/02.0068, research and development project |
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