| PÁCAL, Lukáš, Veronika DVOŘÁKOVÁ, Martina RAUDENSKÁ, Katarína KURICOVÁ, Jaromír GUMULEC, Jan SVOJANOVSKÝ, Jitka ŘEHOŘOVÁ, Branislav RUTTKAY-NEDECKÝ, Ondřej ZÍTKA, René KIZEK, Michal MASAŘÍK and Kateřina KAŇKOVÁ. Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease. In Diabetes - a Threat to Mankind. 2013. |
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@proceedings{1111186,
author = {Pácal, Lukáš and Dvořáková, Veronika and Raudenská, Martina and Kuricová, Katarína and Gumulec, Jaromír and Svojanovský, Jan and Řehořová, Jitka and RuttkayandNedecký, Branislav and Zítka, Ondřej and Kizek, René and Masařík, Michal and Kaňková, Kateřina},
booktitle = {Diabetes - a Threat to Mankind},
title = {Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease},
year = {2013}
}
TY - CONF
ID - 1111186
AU - Pácal, Lukáš - Dvořáková, Veronika - Raudenská, Martina - Kuricová, Katarína - Gumulec, Jaromír - Svojanovský, Jan - Řehořová, Jitka - Ruttkay-Nedecký, Branislav - Zítka, Ondřej - Kizek, René - Masařík, Michal - Kaňková, Kateřina
PY - 2013
TI - Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease
N2 - Oxidative stress and subsequent activation of antioxidant mechanisms (both enzymatic and nonenzymatic) is well established in type 2 diabetes (T2DM). Metallothionein (MT) is a protein binding heavy metal ions (primarily zinc). MT substantially affects zinc metabolism and thus insulin secretion by beta-cell. Zinc levels are often decreased in diabetics due to its increased renal clearance. Association of polymorphism in the gene for zinc transporter (ZnT-8) with T2DM in genome wide association study (Sladek R et al. Nature 2007) underlines the role of zinc for glucose metabolism. We aimed to determine blood levels of selected heavy metals, MT, antioxidants and relevant SNPs in type 2 diabetics with kidney disease (at least microalbuminuric) and healthy subjects.
ER -
PÁCAL, Lukáš, Veronika DVOŘÁKOVÁ, Martina RAUDENSKÁ, Katarína KURICOVÁ, Jaromír GUMULEC, Jan SVOJANOVSKÝ, Jitka ŘEHOŘOVÁ, Branislav RUTTKAY-NEDECKÝ, Ondřej ZÍTKA, René KIZEK, Michal MASAŘÍK and Kateřina KAŇKOVÁ. Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease. In \textit{Diabetes - a Threat to Mankind}. 2013.
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