KNIGHT, Andrea, AJ. MADRIGAL, S. GRACE, J. SIVAKUMARAN, P. KOTTARIDIS, S . MACKINNON, PJ. TRAVERS and MW. LOWDELL. The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation. Blood. Washington, DC, United States: American Society of Hematology, 2010, vol. 116, No 12, p. 2164-72, 9 pp. ISSN 0006-4971. doi:10.1182/blood-2010-01-255166.
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Basic information
Original name The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation
Authors KNIGHT, Andrea, AJ. MADRIGAL, S. GRACE, J. SIVAKUMARAN, P. KOTTARIDIS, S . MACKINNON, PJ. TRAVERS and MW. LOWDELL.
Edition Blood, Washington, DC, United States, American Society of Hematology, 2010, 0006-4971.
Other information
Type of outcome Article in a journal
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 10.558
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1182/blood-2010-01-255166
UT WoS 000282137300026
Keywords in English Receptor Repertoire; Peripheral blood; Infected Persons; Immune-Responses; NKG2d Receptor; CMV Disease; Bone marrow; B-Cells; Lymphocytes; V-Delta-1
Tags International impact, Reviewed
Changed by Changed by: Mgr. Anna Potáčová, Ph.D., učo 44190. Changed: 20/6/2013 13:18.
Abstract
Reactivation of cytomegalovirus (CMV) remains a serious complication after allogeneic stem cell transplantation, but the role of gamma-delta T cells is undefined. We have studied the immune reconstitution of Vdelta2negative (Vdelta2neg) gamma-delta T cells, including Vdelta1 and Vdelta3 subsets and Vdelta2positive (Vdelta2pos) gamma-delta T cells in 40 patients during the first 24 months after stem cell transplantation. Our study shows new evidence for role of gamma-delta T cells in the immune response to CMV reactivation in transplantation recipients.
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