VAŇÁSEK, Jaroslav, Karel ODRÁŽKA, Martin DOLEŽEL, Iveta KOLÁŘOVÁ, Jiří JARKOVSKÝ, Tomáš PAVLÍK, Aleš HLÁVKA and Ladislav DUŠEK. Statistical Analysis of Dose-Volume Profiles and its Implication for Radiation Therapy Planning in Prostate Carcinoma. International Journal of Radiation Oncology Biology Physics, New York: Elsevier Inc., 2013, vol. 86, No 4, p. 769-776. ISSN 0360-3016. doi:10.1016/j.ijrobp.2013.03.018.
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Original name Statistical Analysis of Dose-Volume Profiles and its Implication for Radiation Therapy Planning in Prostate Carcinoma
Authors VAŇÁSEK, Jaroslav (203 Czech Republic), Karel ODRÁŽKA (203 Czech Republic), Martin DOLEŽEL (203 Czech Republic), Iveta KOLÁŘOVÁ (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Aleš HLÁVKA (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic, guarantor, belonging to the institution).
Edition International Journal of Radiation Oncology Biology Physics, New York, Elsevier Inc. 2013, 0360-3016.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10103 Statistics and probability
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.176
RIV identification code RIV/00216224:14110/13:00068772
Organization unit Faculty of Medicine
UT WoS 000320590200035
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 30/7/2013 16:27.
Purpose: The study aimed to analyze the dose-volume profiles of 3-dimensional radiation therapy (3D-CRT) and intensity modulated RT (IMRT) in the treatment of prostate carcinoma and to specify the profiles responsible for the development of gastrointestinal (GI) toxicity. Methods and Materials: In the period 1997 to 2007, 483 patients with prostate carcinoma in stage T1-3 N0 (pN0) M0 were treated with definitive RT. Two groups of patients were defined for the analysis: the 3D-CRT group (n=305 patients) and the IMRT group (n=178 patients). In the entire cohort of 483 patients, the median follow-up time reached 4.4 years (range, 2.0-11.7 years). The cumulative absolute and relative volumes of irradiated rectum exposed to a given dose (area under the dose-volume curve, AUC) were estimated. The receiver operating characteristic analysis was then used to search for the optimal dose and volume cutoff points with the potential to distinguish patients with enhanced or escalated toxicity. Results: Despite the application of high doses (78-82 Gy) in the IMRT group, GI toxicity was lower in that group than in the group treated by 3D-CRT with prescribed doses of 70 to 74 Gy. Both RT methods showed specific rectal dose-volume distribution curves. The total AUC values for IMRT were significantly lower than those for 3D-CRT. Furthermore, IMRT significantly decreased the rectal volume receiving low to intermediate radiation doses in comparison with 3D-CRT; specific cutoff limits predictable for the level of GI toxicity are presented and defined in our work. Conclusions: Total area under the dose-volume profiles and specific cutoff points in low and intermediate dose levels have significant predictive potential toward the RT GI toxicity. In treatment planning, it seems that it is valuable to take into consideration the entire dose-volume primary distribution.
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