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@article{1114533,
author = {Kruzliak, Peter and Pechanová, Olga and Kára, Tomáš},
article_location = {New York},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s10741-013-9397-4},
keywords = {nitric oxide; nitric oxide donors; adenosine cardiac arrest; cardiopulmonary resuscitation},
language = {eng},
issn = {1382-4147},
journal = {Heart Failure Reviews},
title = {New perspectives of nitric oxide donors in cardiac arrest and cardiopulmonary resuscitation treatment},
volume = {19},
year = {2014}
}
TY - JOUR
ID - 1114533
AU - Kruzliak, Peter - Pechanová, Olga - Kára, Tomáš
PY - 2014
TI - New perspectives of nitric oxide donors in cardiac arrest and cardiopulmonary resuscitation treatment
JF - Heart Failure Reviews
VL - 19
IS - 3
SP - 383-390
EP - 383-390
PB - Springer US
SN - 13824147
KW - nitric oxide
KW - nitric oxide donors
KW - adenosine cardiac arrest
KW - cardiopulmonary resuscitation
N2 - Nitric oxide (NO) is often used to treat heart failure accompanied with pulmonary edema. According to present knowledge, however, NO donors are contraindicated when systolic blood pressure is less than 90 mmHg. Based on recent findings and our own clinical experience, we formulated a hypothesis about the new breakthrough complex lifesaving effects of NO donors in patients with cardiac arrest and cardiopulmonary resuscitation therapy. It includes a direct hemodynamic effect of NO donors mediated through vasodilation of coronary arteries in cooperation with improvement of cardiac function and cardiac output through reversible inhibition of mitochondrial complex I and mitochondrial NO synthase, followed by reduction in reactive oxygen species and correction of myocardial stunning. Simultaneously, an increase in vascular sensitivity to sympathetic stimulation could lead to an increase in diastolic blood pressure. Confirmation of this hypothesis in clinical practice would mean a milestone in the treatment for cardiac arrest and cardiopulmonary resuscitation.
ER -
KRUZLIAK, Peter, Olga PECHANOVÁ a Tomáš KÁRA. New perspectives of nitric oxide donors in cardiac arrest and cardiopulmonary resuscitation treatment. \textit{Heart Failure Reviews}. New York: Springer US, 2014, roč.~19, č.~3, s.~383-390. ISSN~1382-4147. doi:10.1007/s10741-013-9397-4.
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