| KRYUKOV, Fedor, Pavel NĚMEC, Elena DEMENTYEVA, Lenka KUBICZKOVÁ, Ivana IHNATOVÁ, Eva BUDINSKÁ, Jiří JARKOVSKÝ, Sabina ŠEVČÍKOVÁ, Petr KUGLÍK and Roman HÁJEK. Molecular heterogeneity and centrosome-associated genes in multiple myeloma. Leukemia & Lymphoma. London: Taylor & Francis, 2013, vol. 54, No 9, p. 1982-1988. ISSN 1042-8194. Available from: https://dx.doi.org/10.3109/10428194.2013.764416. |
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@article{1115105,
author = {Kryukov, Fedor and Němec, Pavel and Dementyeva, Elena and Kubiczková, Lenka and Ihnatová, Ivana and Budinská, Eva and Jarkovský, Jiří and Ševčíková, Sabina and Kuglík, Petr and Hájek, Roman},
article_location = {London},
article_number = {9},
doi = {http://dx.doi.org/10.3109/10428194.2013.764416},
keywords = {Multiple myeloma; centrosome abnormalities; gene expression profile},
language = {eng},
issn = {1042-8194},
journal = {Leukemia & Lymphoma},
title = {Molecular heterogeneity and centrosome-associated genes in multiple myeloma},
volume = {54},
year = {2013}
}
TY - JOUR
ID - 1115105
AU - Kryukov, Fedor - Němec, Pavel - Dementyeva, Elena - Kubiczková, Lenka - Ihnatová, Ivana - Budinská, Eva - Jarkovský, Jiří - Ševčíková, Sabina - Kuglík, Petr - Hájek, Roman
PY - 2013
TI - Molecular heterogeneity and centrosome-associated genes in multiple myeloma
JF - Leukemia & Lymphoma
VL - 54
IS - 9
SP - 1982-1988
EP - 1982-1988
PB - Taylor & Francis
SN - 10428194
KW - Multiple myeloma
KW - centrosome abnormalities
KW - gene expression profile
N2 - In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. We believe that future investigation of this molecular heterogeneity will help to refi ne the broad prognoses off ered by present-day established systems and even sub-stratify them.
ER -
KRYUKOV, Fedor, Pavel NĚMEC, Elena DEMENTYEVA, Lenka KUBICZKOVÁ, Ivana IHNATOVÁ, Eva BUDINSKÁ, Jiří JARKOVSKÝ, Sabina ŠEVČÍKOVÁ, Petr KUGLÍK and Roman HÁJEK. Molecular heterogeneity and centrosome-associated genes in multiple myeloma. \textit{Leukemia \&{} Lymphoma}. London: Taylor \&{} Francis, 2013, vol.~54, No~9, p.~1982-1988. ISSN~1042-8194. Available from: https://dx.doi.org/10.3109/10428194.2013.764416.
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