HLAVSA, Jan, Vladimír PROCHÁZKA, Michal CRHA, Iva SVOBODOVÁ, Tomáš ANDRAŠINA, Petr RAUŠER, Lucie URBANOVÁ, Tomáš PAVLÍK, Jana LORENZOVÁ, Alois NEČAS and Zdeněk KALA. Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study. ACTA VETERINARIA BRNO. Brno: VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, vol. 81, No 4, p. 427-431. ISSN 0001-7213. doi:10.2754/avb201281040427. 2012.
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Basic information
Original name Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study
Authors HLAVSA, Jan (203 Czech Republic, guarantor, belonging to the institution), Vladimír PROCHÁZKA (203 Czech Republic, belonging to the institution), Michal CRHA (203 Czech Republic), Iva SVOBODOVÁ (203 Czech Republic, belonging to the institution), Tomáš ANDRAŠINA (703 Slovakia, belonging to the institution), Petr RAUŠER (203 Czech Republic), Lucie URBANOVÁ (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Jana LORENZOVÁ (203 Czech Republic), Alois NEČAS (203 Czech Republic) and Zdeněk KALA (203 Czech Republic, belonging to the institution).
Edition ACTA VETERINARIA BRNO, Brno, VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2012, 0001-7213.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.393
RIV identification code RIV/00216224:14110/12:00065614
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.2754/avb201281040427
UT WoS 000316430300017
Keywords in English Thermoablation; healing; necrosis; animal model; pig
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 21/10/2013 16:04.
Abstract
Radiofrequency ablation is a tumour destruction method, widely used in human as well veterinary medicine. Recently, it has been applied to pancreatic disorder treatment. However, little is known about healing of the pancreatic parenchyma after radiofrequency ablation as it is important for the prevention of complications and treatment strategy. The aim of this experimental in vivo study on pigs was to evaluate the pancreatic parenchyma healing dynamics after damage by radiofrequency ablation. Radiofrequency ablations of the duodenal lobe of the pancreas were performed on 8 cross-bred laboratory pigs. They were euthanized in pairs at seven, fourteen, forty and eighty days after the procedure. Histological and cytological changes of the ablated zone were evaluated after autopsy. It was proved that pancreatic necrosis after radiofrequency ablation heals by means of fibrotic scar. There was no sign of exocrine and endocrine regeneration, respectively, during 80 days after the procedure. This is the first study verifying that the healing process of an ablation zone in the pancreatic parenchyma after radiofrequency ablation is similar to healing in the liver, lung, heart and other parenchymal organs.
Links
CZ.1.05/1.1.00/02.0068, interní kód MUName: CEITEC - středoevropský technologický institut (Acronym: CEITEC)
Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence
NS10239, research and development projectName: Radiofrekvenční ablace pankreatu
Investor: Ministry of Health of the CR
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