Healing dynamics of porcine pancreatic parenchyma after
radiofrequency ablation - in vivo experimental pilot study

J 2012

Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study

HLAVSA, Jan, Vladimír PROCHÁZKA, Michal CRHA, Iva SVOBODOVÁ, Tomáš ANDRAŠINA et. al.

Basic information

Original name

Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study

Authors

HLAVSA, Jan (203 Czech Republic, guarantor, belonging to the institution), Vladimír PROCHÁZKA (203 Czech Republic, belonging to the institution), Michal CRHA (203 Czech Republic), Iva SVOBODOVÁ (203 Czech Republic, belonging to the institution), Tomáš ANDRAŠINA (703 Slovakia, belonging to the institution), Petr RAUŠER (203 Czech Republic), Lucie URBANOVÁ (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Jana LORENZOVÁ (203 Czech Republic), Alois NEČAS (203 Czech Republic) and Zdeněk KALA (203 Czech Republic, belonging to the institution)

Edition

ACTA VETERINARIA BRNO, Brno, VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2012, 0001-7213

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.393

RIV identification code

RIV/00216224:14110/12:00065614

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2754/avb201281040427

UT WoS

000316430300017

Keywords in English

Thermoablation; healing; necrosis; animal model; pig

Abstract

V originále

Radiofrequency ablation is a tumour destruction method, widely used in human as well veterinary medicine. Recently, it has been applied to pancreatic disorder treatment. However, little is known about healing of the pancreatic parenchyma after radiofrequency ablation as it is important for the prevention of complications and treatment strategy. The aim of this experimental in vivo study on pigs was to evaluate the pancreatic parenchyma healing dynamics after damage by radiofrequency ablation. Radiofrequency ablations of the duodenal lobe of the pancreas were performed on 8 cross-bred laboratory pigs. They were euthanized in pairs at seven, fourteen, forty and eighty days after the procedure. Histological and cytological changes of the ablated zone were evaluated after autopsy. It was proved that pancreatic necrosis after radiofrequency ablation heals by means of fibrotic scar. There was no sign of exocrine and endocrine regeneration, respectively, during 80 days after the procedure. This is the first study verifying that the healing process of an ablation zone in the pancreatic parenchyma after radiofrequency ablation is similar to healing in the liver, lung, heart and other parenchymal organs.

Links

CZ.1.05/1.1.00/02.0068, interní kód MU

Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC)

Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence

NS10239, research and development project

Name: Radiofrekvenční ablace pankreatu

Investor: Ministry of Health of the CR

Citovat

HLAVSA, Jan, Vladimír PROCHÁZKA, Michal CRHA, Iva SVOBODOVÁ, Tomáš ANDRAŠINA, Petr RAUŠER, Lucie URBANOVÁ, Tomáš PAVLÍK, Jana LORENZOVÁ, Alois NEČAS and Zdeněk KALA. Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study. ACTA VETERINARIA BRNO. Brno: VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2012, vol. 81, No 4, p. 427-431. ISSN 0001-7213. Available from: https://dx.doi.org/10.2754/avb201281040427.

@article{1115118,
   author = {Hlavsa, Jan and Procházka, Vladimír and Crha, Michal and Svobodová, Iva and Andrašina, Tomáš and Raušer, Petr and Urbanová, Lucie and Pavlík, Tomáš and Lorenzová, Jana and Nečas, Alois and Kala, Zdeněk},
   article_location = {Brno},
   article_number = {4},
   doi = {http://dx.doi.org/10.2754/avb201281040427},
   keywords = {Thermoablation; healing; necrosis; animal model; pig},
   language = {eng},
   issn = {0001-7213},
   journal = {ACTA VETERINARIA BRNO},
   title = {Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study},
   volume = {81},
   year = {2012}
}

TY  - JOUR
ID  - 1115118
AU  - Hlavsa, Jan - Procházka, Vladimír - Crha, Michal - Svobodová, Iva - Andrašina, Tomáš - Raušer, Petr - Urbanová, Lucie - Pavlík, Tomáš - Lorenzová, Jana - Nečas, Alois - Kala, Zdeněk
PY  - 2012
TI  - Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study
JF  - ACTA VETERINARIA BRNO
VL  - 81
IS  - 4
SP  - 427-431
EP  - 427-431
PB  - VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO
SN  - 00017213
KW  - Thermoablation
KW  - healing
KW  - necrosis
KW  - animal model
KW  - pig
N2  - Radiofrequency ablation is a tumour destruction method, widely used in human as well veterinary medicine. Recently, it has been applied to pancreatic disorder treatment. However, little is known about healing of the pancreatic parenchyma after radiofrequency ablation as it is important for the prevention of complications and treatment strategy. The aim of this experimental in vivo study on pigs was to evaluate the pancreatic parenchyma healing dynamics after damage by radiofrequency ablation. Radiofrequency ablations of the duodenal lobe of the pancreas were performed on 8 cross-bred laboratory pigs. They were euthanized in pairs at seven, fourteen, forty and eighty days after the procedure. Histological and cytological changes of the ablated zone were evaluated after autopsy. It was proved that pancreatic necrosis after radiofrequency ablation heals by means of fibrotic scar. There was no sign of exocrine and endocrine regeneration, respectively, during 80 days after the procedure. This is the first study verifying that the healing process of an ablation zone in the pancreatic parenchyma after radiofrequency ablation is similar to healing in the liver, lung, heart and other parenchymal organs.
ER  -

HLAVSA, Jan, Vladimír PROCHÁZKA, Michal CRHA, Iva SVOBODOVÁ, Tomáš ANDRAŠINA, Petr RAUŠER, Lucie URBANOVÁ, Tomáš PAVLÍK, Jana LORENZOVÁ, Alois NEČAS and Zdeněk KALA. Healing dynamics of porcine pancreatic parenchyma after radiofrequency ablation - in vivo experimental pilot study. \textit{ACTA VETERINARIA BRNO}. Brno: VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2012, vol.~81, No~4, p.~427-431. ISSN~0001-7213. Available from: https://dx.doi.org/10.2754/avb201281040427.

Detailed Information on Publication Record