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@article{1115205,
author = {RuttkayandNedecky, Branislav and Nejdl, Lukáš and Gumulec, Jaromír and Zitka, Ondřej and Masařík, Michal and Eckschlager, Tomáš and Stiborová, Marie and Adam, Vojtěch and Kizek, René},
article_location = {Basel},
article_number = {3},
doi = {http://dx.doi.org/10.3390/ijms14036044},
keywords = {metallothionein; free radicals; cellular oxidative stress; zinc; transcription factor; cancer},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {The Role of Metallothionein in Oxidative Stress},
volume = {14},
year = {2013}
}
TY - JOUR
ID - 1115205
AU - Ruttkay-Nedecky, Branislav - Nejdl, Lukáš - Gumulec, Jaromír - Zitka, Ondřej - Masařík, Michal - Eckschlager, Tomáš - Stiborová, Marie - Adam, Vojtěch - Kizek, René
PY - 2013
TI - The Role of Metallothionein in Oxidative Stress
JF - International Journal of Molecular Sciences
VL - 14
IS - 3
SP - 6044-6066
EP - 6044-6066
PB - MDPI Center
SN - 14220067
KW - metallothionein
KW - free radicals
KW - cellular oxidative stress
KW - zinc
KW - transcription factor
KW - cancer
N2 - Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are highlighted.
ER -
RUTTKAY-NEDECKY, Branislav, Lukáš NEJDL, Jaromír GUMULEC, Ondřej ZITKA, Michal MASAŘÍK, Tomáš ECKSCHLAGER, Marie STIBOROVÁ, Vojtěch ADAM a René KIZEK. The Role of Metallothionein in Oxidative Stress. \textit{International Journal of Molecular Sciences}. Basel: MDPI Center, 2013, roč.~14, č.~3, s.~6044-6066. ISSN~1422-0067. doi:10.3390/ijms14036044.
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