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RUTTKAY-NEDECKY, Branislav, Lukáš NEJDL, Jaromír GUMULEC, Ondřej ZITKA, Michal MASAŘÍK, Tomáš ECKSCHLAGER, Marie STIBOROVÁ, Vojtěch ADAM and René KIZEK. The Role of Metallothionein in Oxidative Stress. International Journal of Molecular Sciences. Basel: MDPI Center, 2013, vol. 14, No 3, p. 6044-6066. ISSN 1422-0067. doi:10.3390/ijms14036044.
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Basic information
Original name The Role of Metallothionein in Oxidative Stress
Authors RUTTKAY-NEDECKY, Branislav (203 Czech Republic), Lukáš NEJDL (203 Czech Republic), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Ondřej ZITKA (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution), Tomáš ECKSCHLAGER (203 Czech Republic), Marie STIBOROVÁ (203 Czech Republic), Vojtěch ADAM (203 Czech Republic) and René KIZEK (203 Czech Republic).
Edition International Journal of Molecular Sciences, Basel, MDPI Center, 2013, 1422-0067.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.339
RIV identification code RIV/00216224:14110/13:00068802
Organization unit Faculty of Medicine
UT WoS 000316609800090
Keywords in English metallothionein; free radicals; cellular oxidative stress; zinc; transcription factor; cancer
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 14. 10. 2013 08:32.
Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are highlighted.
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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